• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pediatric allergy and immunology: official publication of the European Society of Pediatric Allergy and Immunology >Problematic severe asthma: a proposed approach to identifying children who are severely resistant to therapy.
【24h】

Problematic severe asthma: a proposed approach to identifying children who are severely resistant to therapy.

机译：有问题的严重哮喘：一种鉴定对治疗严重耐药的儿童的建议方法。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Children with problematic severe asthma (PA) are either difficult to treat because of the presence of aggravating factors or else severely resistant to therapy. We investigated a cohort of school-aged children with PA and compared these children to age-matched peers with controlled persistent asthma (CA). The aims were to characterize features of children suffering from PA and identify children who were severely resistant to therapy. In this cross-sectional, multicenter comparison of children with different manifestations of persistent asthma, PA was defined as insufficient asthma control despite level 4 treatment, according to GINA. The protocol included questionnaires, spirometry, methacholine provocation, measurement of fraction of nitric oxide in exhaled (FE(NO) ) and nasal air, blood sampling for inflammatory biomarkers and atopy, and computerized tomography of sinuses and lungs (in the PA group only). Of the 54 children with PA, 61% had therapy-resistant asthma, with the remaining being difficult to treat because of identified aggravating factors. Children with PA more often had parents with asthma (p=0.003), came from families with a lower socioeconomic status (p=0.01), were less physically active (p=0.04), and had more comorbidity with rhinoconjunctivitis (p=0.01) than did the 39 children with CA. The former also exhibited lower FEV(1) values (p=0.02) and increased bronchial hyper-responsiveness (p=0.01), but there were no differences in atopy (p=0.81) or FE(NO) (p=0.16). A non-invasive protocol, involving a standardized and detailed clinical characterization, revealed distinguishing features of children with PA and enabled the identification of children with therapy-resistant asthma.
机译：患有严重哮喘（PA）的儿童由于存在加重因素而难以治疗，或者对治疗有严重抵抗力。我们调查了一群学龄期PA患儿，并将这些患儿与年龄相匹配的患有持续性哮喘（CA）的同龄人进行了比较。目的是表征患有PA的儿童的特征，并确定对治疗有严重抵抗力的儿童。根据GINA，在此横断面，多中心比较的不同表现形式的持续性哮喘儿童中，PA被定义为尽管进行了4级治疗，仍无法有效控制哮喘。该方案包括问卷，肺活量测定法，乙酰甲胆碱激发，呼出气（FE（NO））和鼻空气中一氧化氮含量的测量，炎性生物标志物和特应性的血液采样以及鼻窦和肺部计算机断层扫描（仅在PA组中） 。在54名PA患儿中，有61％患有抗药性哮喘，其余的由于确定的加重因素而难以治疗。 PA患儿的父母多为哮喘（p = 0.003），来自社会经济地位较低的家庭（p = 0.01），体力活动较弱（p = 0.04），并且患有鼻结膜炎的合并症更多（p = 0.01）比39名患有CA的儿童要多。前者还表现出较低的FEV（1）值（p = 0.02）和增加的支气管高反应性（p = 0.01），但特应性（p = 0.81）或FE（NO）（p = 0.16）没有差异。一项涉及标准化和详细临床特征的非侵入性治疗方案揭示了PA儿童的显着特征，并使他们能够鉴定出具有治疗抵抗力的哮喘儿童。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号