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Antibacterial activity, fluoride release, and physical properties of an antibioticmodified glass ionomer cement

机译：抗生素改性的玻璃离聚物水泥的抗菌活性，氟化物释放和物理性质

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Purpose: This study's purpose was to examine the influence of adding an antibiotic mixture to conventional glass ionomer cement (GIC) on its antibacterial activity, fluoride-releasing ability, and physical properties. Methods: An antibiotic mixture containing ciprofloxacin and metronidazole was added to GIC at concentration ratios of one percent weight antibiotic/ weight total powder before mixing (w/w; Group 1) and two percent w/w (Group 2) to obtain the test groups. Conventional GIC served as the control. The antibacterial activity of the cement specimens was evaluated against Streptococcus mutans and Lactobacillus casei using the agar inhibition test. The fluoride release from the cement specimens was evaluated using a fluoride ion selective electrode. The physical parameters evaluated were net setting time, compressive strength, shear bond strength, and microleakage. Results: Group 2 showed a significantly greater inhibition zone than Group 1 against both tested organisms, while the control did not inhibit organism growth. The addition of antibiotics at one percent and two percent to GIC enhanced its fluoride release. At two percent, however, the physical properties of GIC were adversely affected. Conclusion: Antibiotics at one percent weight solute/weight total solution after mixing may modestly confer an antibacterial activity to glass ionomer cement and enhance its fluoride-releasing ability. Its effects on shear bond strength and microleakage were found to be encouraging.
机译：目的：本研究的目的是研究向常规玻璃离聚物水泥（GIC）中添加抗生素混合物对其抗菌活性，氟化物释放能力和物理性能的影响。方法：将含有环丙沙星和甲硝唑的抗生素混合物以占混合前总重量1％的抗生素/总粉末（w / w;第1组）和2％w / w（第2组）的浓度比加入GIC。 。常规GIC作为对照。使用琼脂抑制试验评估水泥样品的抗变形链球菌和干酪乳杆菌的抗菌活性。使用氟离子选择性电极评估了水泥样品中的氟释放量。评估的物理参数为净凝固时间，抗压强度，剪切粘结强度和微渗漏。结果：第2组对两种受试生物均显示出比第1组明显更大的抑制区，而对照未抑制生物生长。在GIC中添加1％和2％的抗生素可增加其氟化物的释放。但是，GIC的物理性能为2％时会受到不利影响。结论：混合后，溶质/总溶液重量为1％时，抗生素可以适度地赋予玻璃离聚物水泥以抗菌作用，并增强其氟释放能力。发现其对剪切粘结强度和微渗漏的影响是令人鼓舞的。

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