...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pediatric diabetes. >Soluble CD40L in children and adolescents with type 1 diabetes: relation to microvascular complications and glycemic control
【24h】

Soluble CD40L in children and adolescents with type 1 diabetes: relation to microvascular complications and glycemic control

机译：1型糖尿病儿童和青少年的可溶性CD40L：与微血管并发症和血糖控制的关系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

CD40-soluble CD40 ligand (sCD40L) interactions might constitute an important mediator for vascular inflammation that initiates diabetic microangiopathy. Little is known about the relation between sCD40L and glycemic control. Therefore, this study aimed to evaluate sCD40L levels in patients with type 1 diabetes and its relation to microvascular complications and metabolic control. Sixty patients with type 1 diabetes were compared with 30 healthy control subjects. Detailed medical history, thorough clinical examination, and laboratory assessment of high-sensitivity C-reactive protein, glycemic control, and the presence of microvascular complications were performed. Measurement of serum sCD40L levels was done using enzyme-linked immunosorbent assay. Patients were divided into two groups according to the presence of microvascular complications. Serum sCD40L levels were significantly elevated in patients with type 1 diabetes in both groups compared with healthy controls (p < 0.001). Patients with microvascular complications had higher serum sCD40L concentrations than non-complicated cases (median, 13?000 vs. 450?pg/mL; p < 0.001). Serum sCD40L cutoff value of 530?pg/mL was able to differentiate complicated from non-complicated cases (p < 0.001). Patients with microalbuminuria or peripheral neuropathy showed higher levels of sCD40L when compared with patients without these complications (p < 0.05). Serum sCD40L levels were positively correlated with hemoglobin A1c and urinary albumin excretion (p < 0.001). We suggest that serum sCD40L levels are elevated in type 1 diabetes, particularly in patients with microvascular complications and a significant correlation with glycemic control exists. Therefore, measurement of serum sCD40L levels in poorly controlled patients would help to identify those at high risk of developing microvascular complications.
机译：CD40可溶性CD40配体（sCD40L）相互作用可能构成引发糖尿病微血管病的血管炎症的重要介质。关于sCD40L和血糖控制之间的关系知之甚少。因此，本研究旨在评估1型糖尿病患者的sCD40L水平及其与微血管并发症和代谢控制的关系。将60名1型糖尿病患者与30名健康对照受试者进行比较。进行了详细的病史，全面的临床检查以及对高敏C反应蛋白，血糖控制和微血管并发症的实验室评估。使用酶联免疫吸附测定法测量血清sCD40L水平。根据微血管并发症的存在将患者分为两组。与健康对照组相比，两组1型糖尿病患者的血清sCD40L水平均显着升高（p <0.001）。具有微血管并发症的患者的血清sCD40L浓度高于无并发症的患者（中位数为13？000 vs. 450？pg / mL; p <0.001）。血清sCD40L截止值为530？pg / mL能够区分复杂病例和非复杂病例（p <0.001）。与没有这些并发症的患者相比，患有微量白蛋白尿或周围神经病的患者显示更高的sCD40L水平。血清sCD40L水平与血红蛋白A1c和尿白蛋白排泄呈正相关（p <0.001）。我们建议在1型糖尿病患者中血清sCD40L水平升高，尤其是在微血管并发症患者中，并且与血糖控制存在显着相关性。因此，在控制不佳的患者中测量血清sCD40L的水平将有助于鉴定那些发生微血管并发症的高风险人群。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号