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首页> 外文期刊>Pediatric diabetes. >Ascorbic acid blocks hyperglycemic impairment of endothelial function in adolescents with type 1 diabetes
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Ascorbic acid blocks hyperglycemic impairment of endothelial function in adolescents with type 1 diabetes

机译：抗坏血酸可阻止1型糖尿病青少年的内皮功能高血糖损害

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Objective To determine whether acute ascorbic acid infusions alter the effect of hyperglycemia on endothelial function in adolescents with type 1 diabetes. Research design and methods The forearm blood flow (FBF) reactive hyperemic response to 5?min of upper arm occlusion was studied in eight adolescents with type 1 diabetes during euglycemic and hyperglycemic insulin clamp (40?mU/m2/min) with and without ascorbic acid infusion (3?mg/min). Results The ratio of post- to preocclusion FBF decreased during hyperglycemia without ascorbic acid (p?=?0.013), but did not change during hyperglycemia with ascorbic acid. The changes during hyperglycemia were different between the two studies (p?=?0.038). Similar results were found when the percent change in forearm vascular resistance following occlusion was assessed. Conclusions These results indicate that antioxidant treatment with ascorbic acid blocks acute hyperglycemic impairment of endothelial function in adolescents with type 1 diabetes.
机译：目的确定急性抗坏血酸输注是否改变高血糖对1型糖尿病青少年内皮功能的影响。研究设计和方法研究了8名1型糖尿病青少年在正常血糖和高血糖胰岛素钳制期间（40？mU / m2 / min）有无抗坏血酸时，对上臂阻塞5？min的前臂血流（FBF）反应性充血反应。酸输注（3？mg / min）。结果高血糖时无抗坏血酸时，闭塞后FBF的比率降低（p？=？0.013），而抗坏血酸高血糖时，无变化。高血糖期间的变化在两项研究之间是不同的（p = 0.038）。当评估闭塞后前臂血管阻力的百分比变化时，发现了相似的结果。结论这些结果表明，抗坏血酸的抗氧化剂治疗可阻断1型糖尿病青少年急性内皮功能的高血糖损害。

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