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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Serum antibodies to retinal antigens in lung cancer and sarcoidosis.
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Serum antibodies to retinal antigens in lung cancer and sarcoidosis.

机译：肺癌和结节病中针对视网膜抗原的血清抗体。

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OBJECTIVE: Autoantibodies to various neuronal proteins frequently accompany lung cancer and their appearance may precede cancer symptoms. In this study we examined which retinal antigens (RAs) are recognized by sera of patients with lung cancer and whether the occurrence of serum antibodies to particular RAs is characteristic for cancer in comparison with a noncancer lung disease. METHODS: Sera of 72 patients with non-small-cell lung cancer (NSCLC), 29 with small-cell lung cancer (SCLC), 27 with sarcoidosis (S), and sera of 32 healthy donors were examined in immunoblotting using retinal extracts and purified RAs as antigens. RESULTS: 69.0% of SCLC, 45.8% of NSCLC, and 44.4% of S sera displayed anti-RAs reactivity. Significantly less (p < 0.05; chi(2) test) percent of healthy control sera reacted with RAs. Lung cancer sera recognized mainly 46-, 56-, and 36-kD and to a smaller extent also 96-, 72-, 43-, and 26-kD proteins. Most of them were recognized with about 2-fold lower frequencies by S and control sera. Only lung cancer sera contained very high-titer antibodies to 46- and 26-kD RAs, identified as alpha-enolase and recoverin, respectively. CONCLUSION: Antibodies to RAs occur more frequently and in higher titers in lung cancer (especially SCLC) than in sarcoidosis or control sera. Although antibodies to retinal alpha-enolase, recoverin and other RAs are present mainly or exclusively in lung cancer sera, none of them seems to be a specific marker of a particular disease.
机译：目的：针对多种神经元蛋白的自身抗体经常伴有肺癌，其出现可能早于癌症症状。在这项研究中，我们检查了肺癌患者血清中可识别哪些视网膜抗原（RA），以及与非癌性肺病相比，针对特定RA的血清抗体的出现是否是癌症的特征。方法：采用视网膜提取液和免疫组化方法检测了72例非小细胞肺癌（NSCLC），29例小细胞肺癌（SCLC），27例结节病（S）患者的血清和32例健康供体的血清。纯化的RA作为抗原。结果：69.0％的SCLC，45.8％的NSCLC和44.4％的S血清表现出抗RAs反应性。健康对照血清与RA发生反应的百分比显着降低（p <0.05; chi（2）测试）。肺癌血清主要识别46 kD，56 kD和36 kD，在较小程度上还识别96 kD，72 kD，43 kD和26 kD蛋白。它们中的大多数被S和对照血清识别的频率降低了约2倍。只有肺癌血清含有针对46-kD RA和26-kD RA的非常高滴度的抗体，分别鉴定为α-烯醇酶和Recoveryin。结论：与结节病或对照血清相比，肺癌（尤其是SCLC）中RA抗体的发生频率更高且滴度更高。尽管针对视网膜α-烯醇酶，recoverin和其他RA的抗体主要或仅存在于肺癌血清中，但它们似乎都不是特定疾病的特异性标志物。

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