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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Perspectives on resorbable osteosynthesis materials in craniomaxillofacial surgery
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Perspectives on resorbable osteosynthesis materials in craniomaxillofacial surgery

机译：颅颌面外科手术中可吸收的骨合成材料的前景

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摘要

Since introduction to the clinics in the 1990s, resorbable osteosynthesis systems have undergone extensive improvements in order to establish their use as a standard treatment, especially in craniomaxillofacial surgery. However, the development of osteosynthesis systems made of poly(α-hydroxy acid) polymers has been hindered by the lack of information on the mechanical properties and biocompatibility of these materials. Moreover, magnesium-based degredable osteosynthesis materials have not yet been integrated into clinical practice owing to biocompatibility problems. Osteosynthesis systems made from nonresorbable titanium alloys have shown excellent biocompatibility, stability and individual fitting to the implant bed, so these materials are currently considered the 'gold standard'. The procedure of plate removal has been subjected to intense scrutiny and controversy. Bioresorbable materials are indicated for special conditions, such as osteosynthesis of the growing skull or orbital floor reconstructions. This paper presents an overview of the currently available and investigated resorbable osteosynthesis materials in comparison with the nonresorbable 'gold standard' titanium. The main problem areas such as sterilization, biocompatibility and stability are highlighted and perspectives for further improvements are provided.
机译：自1990年代进入临床以来，可吸收的骨合成系统已进行了广泛的改进，以确立其作为标准治疗的用途，尤其是在颅颌面部外科手术中。然而，由于缺乏关于这些材料的机械性能和生物相容性的信息，阻碍了由聚（α-羟基酸）聚合物制成的骨合成系统的发展。此外，由于生物相容性问题，镁基可降解的骨合成材料尚未被整合到临床实践中。由不可吸收的钛合金制成的骨合成系统显示出优异的生物相容性，稳定性和可与植入床完美结合的特性，因此这些材料目前被认为是“黄金标准”。去除板的过程已经受到严格的审查和争议。生物可吸收材料适用于特殊情况，例如不断增长的头骨的骨合成或眶底重建。本文介绍了与不可吸收的“金标准”钛相比，目前可利用和研究的可吸收骨合成材料的概况。重点介绍了主要问题领域，例如灭菌，生物相容性和稳定性，并提供了进一步改进的前景。

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