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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Large-scale analysis of cell cycle regulators in urothelial bladder cancer identifies p16 and p27 as potentially useful prognostic markers.
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Large-scale analysis of cell cycle regulators in urothelial bladder cancer identifies p16 and p27 as potentially useful prognostic markers.

机译：尿路上皮膀胱癌中细胞周期调节因子的大规模分析确定p16和p27是潜在有用的预后标志物。

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AIMS: We investigated the value of multiple cell cycle markers for their prognostic impact on overall survival and recurrence-free survival in urothelial carcinoma (UC). METHODS: A tissue microarray consisting of 99 UCs was evaluated for the expression of p53, p16, p21, p27, cyclin D1, cyclin E , Bcl-2, Ki-67 and PCNA. Statistical analysis was performed applying Kaplan-Meier and Cox regression models using receiver operator characteristic curves for determination of markers' cutoffs. RESULTS: Expression above the cutoffs of Ki-67, p53 and p27, particularly in high-grade and early-stage UC, was associated with worse overall survival, while expression of p16 indicated a better outcome in low-grade and low-stage tumors. Recurrence-free survival was better in patients with high-grade UC expressing PCNA, p16 and cyclin E, and low-grade UC expressing Bcl-2 above the cutoffs, but worse in all tumors with high Ki-67. CONCLUSION: Cell cycle deregulation in UC is complex and the prognostic value of the various involved proteins should be differentially regarded with respect to this complexity and other tumor characteristics such as grade and stage. Our results point towards the role of p16- and p27-associated pathways in tumor progression and indicate that, by using standardized approaches for tissue antigen expression, evaluation and cutoff determination, single potentially useful prognostic markers could be identified.
机译：目的：我们研究了多种细胞周期标志物对尿路上皮癌（UC）整体生存和无复发生存的预后影响的价值。方法：评估由99个UC组成的组织微阵列的p53，p16，p21，p27，cyclin D1，cyclin E，Bcl-2，Ki-67和PC​​NA的表达。应用Kaplan-Meier和Cox回归模型进行统计分析，使用接收者算子特征曲线确定标记的截止值。结果：Ki-67，p53和p27截止值以上的表达，特别是在高级别和早期UC中，与总体生存期较差有关，而p16的表达表明在低级别和低级别肿瘤中预后较好。具有高表达UC的PCNA，p16和cyclin E，以及低表达UC的Bcl-2的UC患者的无复发生存率更高，但在所有Ki-67高的肿瘤中均较差。结论：UC中细胞周期的失调是复杂的，在这种复杂性和其他肿瘤特征（例如等级和分期）方面，应区别考虑各种相关蛋白质的预后价值。我们的结果指出了p16和p27相关途径在肿瘤进展中的作用，并表明，通过使用标准化的方法进行组织抗原表达，评估和确定临界值，可以鉴定出单个可能有用的预后标志物。

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