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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Do different disorders in cell cycle regulation account for different biological behavior of urothelial and sinonasal inverted papillomas?
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Do different disorders in cell cycle regulation account for different biological behavior of urothelial and sinonasal inverted papillomas?

机译：细胞周期调节的不同障碍是否解释了尿路上皮和鼻窦倒置性乳头瘤的不同生物学行为？

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OBJECTIVE: It was the aim of this study to assess the expression of selected cell cycle regulation genes in urothelial and sinonasal inverted papillomas (IP). METHODS: Archived surgically resected specimens from 18 urothelial and 19 sinonasal IP were studied immunohistochemically for p16, p53, cyclin D1 and Ki67. Staining results were semiquantified and compared between IP and adjacent control mucosa (CM). RESULTS: p53 expression did not differ between sinonasal and urothelial IP. Although there was a trend of higher p53 expression in IP compared with the adjacent CM in sinonasal and urothelial specimens, this trend failed to be statistically significant. p16 expression was significantly higher in urothelial IP and CM in comparison with their sinonasal counterparts, but did not differ significantly between IP and its adjacent CM either in urothelial or sinonasal specimens. There were no significant differences in the mean scores for cyclin D1 or Ki67. CONCLUSION: The changes in p53 expression seen in both types of IP compared with adjacent CM suggest that sinonasal and urothelial IP may share some common ground in terms of their evolution. Although p16 appears not to be directly involved in the development of sinonasal or urothelial IP, the differing recurrence patterns of sinonasal versus urothelial IP may be attributable in part to different p16 expression.
机译：目的：本研究旨在评估所选的细胞周期调控基因在尿路上皮和鼻窦倒置性乳头状瘤（IP）中的表达。方法：采用免疫组织化学方法对18例尿路上皮和19例鼻窦IP的手术切除标本进行了免疫组织化学研究，以检测p16，p53，cyclin D1和Ki67。对染色结果进行半定量，并在IP和邻近的对照黏膜（CM）之间进行比较。结果：鼻窦和尿路上皮IP之间的p53表达没有差异。尽管鼻窦和尿路上皮标本中与邻近的CM相比，IP中有更高的p53表达趋势，但这种趋势在统计学上没有统计学意义。与上鼻窦对应物相比，尿路上皮IP和CM中的p16表达显着更高，但在上皮或鼻窦样本中IP及其相邻CM之间的p16表达没有显着差异。 cyclin D1或Ki67的平均得分没有显着差异。结论：与邻近的CM相比，在两种IP类型中看到的p53表达的变化表明，鼻腔和尿路上皮IP可能在进化方面具有某些共同点。尽管p16似乎并不直接参与鼻窦或尿路上皮IP的发展，但是鼻窦与尿路上皮IP的不同复发模式可能部分归因于不同的p16表达。

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