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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Comparative genomic hybridisation arrays: high-throughput tools to determine targeted therapy in breast cancer.
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Comparative genomic hybridisation arrays: high-throughput tools to determine targeted therapy in breast cancer.

机译：比较基因组杂交阵列：确定乳腺癌靶向治疗的高通量工具。

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摘要

Microarray-based comparative genomic hybridisation (aCGH) is contributing to the molecular characterisation of solid malignancies. This technique provides tremendous opportunities for translational research by facilitating detailed analysis of entire cancer genomes in a single experiment with unprecedented resolution. Apart from providing data to help catalogue the molecular genetic profiles of breast cancers and breast cancer cell lines, aCGH has also proven to be a useful technique for the identification of novel therapeutic targets. However, aCGH alone does not provide all lines of evidence required for the identification of 'amplicon drivers' and 'druggable targets'. This can be more effectively achieved by integrating data from aCGH, expression profiling and RNA interference experiments. In this review, we discuss the techniques available for aCGH analysis and possible approaches for using aCGH as a tool for the identification of novel therapeutic targets.
机译：基于微阵列的比较基因组杂交（aCGH）有助于固体恶性肿瘤的分子表征。通过在具有空前分辨率的单个实验中促进对整个癌症基因组的详细分析，该技术为翻译研究提供了巨大的机会。除了提供数据以帮助分类乳腺癌和乳腺癌细胞系的分子遗传图谱外，aCGH还被证明是用于鉴定新型治疗靶标的有用技术。但是，仅aCGH并不能提供识别“ amplicon驾驶员”和“易燃目标”所需的所有证据。通过整合来自aCGH，表达谱和RNA干扰实验的数据，可以更有效地实现这一目标。在这篇综述中，我们讨论了可用于aCGH分析的技术以及使用aCGH作为识别新型治疗靶标的工具的可能方法。

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