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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Cyclin D1, retinoblastoma, p53, and Her2eu protein expression in preinvasive breast pathologies: correlation with vascularity.
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Cyclin D1, retinoblastoma, p53, and Her2eu protein expression in preinvasive breast pathologies: correlation with vascularity.

机译：浸润前乳腺病理学中的Cyclin D1，视网膜母细胞瘤，p53和Her2 / neu蛋白表达：与血管的相关性。

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OBJECTIVES: Preinvasive breast pathologies show a degree of vascularization that correlates with risk of invasion. Recently, numerous oncogenes and tumor suppressor genes have been shown to regulate neovascularization. Therefore, we examined archival tissues of preinvasive breast pathologies by immunohistochemistry for alterations in the expression of four proteins, cyclin D1, retinoblastoma (Rb), p53, and Her2eu, known to be important in breast tumorgenesis, and correlated these data with tissue vascularity. METHODS: Vascularity was determined by immunologic detection of von Willebrand factor. For carcinoma in situ (CIS) both stromal vascularity (MVD) and vascular cuffing (MCD) were determined. RESULTS: We found that cyclin D1 expression was increased in usual hyperplasia (11% of cases). Atypical hyperplasia, noncomedo CIS and comedo CIS were positive in 43, 49, and 57% of cases, respectively. Changes in Rb and p53 were rare in hyperplasia but occurred in 8 and 10% of CIS, respectively. Her2eu protein was identified rarely in atypical hyperplasia and in both noncomedo and comedo ductal CIS. Neither Rb nor Her2eu expression correlated with vascularity. p53 immunoreactivity correlated positively with both MCD and MVD. Cyclin D1 was negatively associated with MVD. CONCLUSION: These data suggest that p53 and cyclin D1 proteins may regulate the microvessel density of preinvasive breast pathologies. Copyright 2001 S. Karger AG, Basel
机译：目的：浸润前乳腺病理显示一定程度的血管形成与浸润风险相关。近来，已经显示出许多癌基因和肿瘤抑制基因调节新血管形成。因此，我们通过免疫组织化学检查了浸润前乳腺病理的档案组织中四种蛋白，cyclin D1，视网膜母细胞瘤（Rb），p53和Her2 / neu的表达，这些蛋白在乳腺肿瘤的发生中起着重要的作用，并将这些数据与组织相关联。血管性。方法：通过免疫检测von Willebrand因子确定血管。对于原位癌（CIS），确定了间质血管（MVD）和血管套扎（MCD）。结果：我们发现，在正常的增生中，细胞周期蛋白D1的表达增加了（占病例的11％）。非典型增生，非粉刺CIS和粉刺CIS分别为43、49和57％。 Rb和p53的变化在增生中很少见，但分别发生在CIS的8％和10％。在非典型增生以及非粉刺和粉刺导管CIS中很少发现Her2 / neu蛋白。 Rb和Her2 / neu表达均与血管性无关。 p53免疫反应性与MCD和MVD呈正相关。细胞周期蛋白D1与MVD呈负相关。结论：这些数据表明p53和细胞周期蛋白D1蛋白可能调节浸润前乳腺病理的微血管密度。版权所有2001 S. Karger AG，巴塞尔

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