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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Immunopathological factors for vertical transmission of HIV-1.
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Immunopathological factors for vertical transmission of HIV-1.

机译：HIV-1垂直传播的免疫病理因素。

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摘要

With the global rise in human immunodeficiency virus-1 (HIV-1) infection in women of childbearing age, there has also been an alarming rise in the number of mother-to-child transmissions of HIV-1. Although drug therapies such as zidovudine as well as nevirapine have been demonstrated to significantly decrease the incidence of vertical transmission of HIV-1, these therapeutic regimens are still not widely available in some developing countries where maternal-to-child transmission of HIV-1 continues to occur at an alarming rate. Therefore, the continued studies of mechanisms and correlates of vertical transmission of HIV-1 are warranted. The current status of immunological and virological correlates of vertical transmission are summarized in this review. In addition, information concerning recent therapeutic agents for the prevention of HIV-1 vertical transmission is presented. Copyright 2000 S. Karger AG, Basel
机译：随着全球育龄妇女中人类免疫缺陷病毒1（HIV-1）感染的上升，HIV-1母婴传播的数量也惊人地增加。尽管已证明诸如齐多夫定和奈韦拉平之类的药物疗法可显着降低HIV-1垂直传播的发生率，但在某些继续由母婴传播HIV-1的发展中国家中，仍无法广泛使用这些治疗方案以惊人的速度发生。因此，有必要继续研究HIV-1垂直传播的机制及其相关性。本文综述了垂直传播的免疫学和病毒学相关性的现状。此外，介绍了有关预防HIV-1垂直传播的最新治疗剂的信息。版权所有2000 S. Karger AG，巴塞尔

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