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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Differential effects of sex steroids on T and B cells: modulation of cell cycle phase distribution, apoptosis and bcl-2 protein levels.
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Differential effects of sex steroids on T and B cells: modulation of cell cycle phase distribution, apoptosis and bcl-2 protein levels.

机译：性类固醇对T细胞和B细胞的差异作用：调节细胞周期的相位分布，凋亡和bcl-2蛋白水平。

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摘要

Sex steroids have dramatic and differential effects on classic endocrine organ proliferation and apoptosis. In this investigation we sought to delineate similar effects of sex steroids on proliferation, cell cycle phase and apoptosis in lymphocyte cell lines as models for T and B cells. Estrogen and testosterone inhibited T cell line proliferation, induced accumulation of cells in S/G(2)M phases of the cell cycle, and increased apoptosis in a concentration- and time-dependent manner. There was a more modest effect of estrogen and testosterone on cell cycling and apoptosis in B lymphocyte cell lines, suggesting that estrogen and testosterone are inhibitory to T but not B cell lines. In comparison, progesterone induced cytostasis and modestly increased apoptosis in both T and B cell lines. Estrogen and testosterone were not antagonistic or synergistic to each other in their effects on cell cycle phase distribution, and only minimally synergistic for apoptosis. In contrast, progesterone antagonized cell cycle and apoptotic effects of estrogen in T cells. Estrogen-induced cell cycle and apoptotic effects in T cell lines were associated with suppression of bcl-2 protein levels, which were unaffected in Raji B cells. Progesterone also antagonized the estrogen-induced changes in T cell bcl-2 protein levels. These results suggest that there may be significant and differential sex steroid effects on T and B lymphocytes that may be important to sexual dichotomies in immune and autoimmune responses. Copyright 2001 S. Karger AG, Basel
机译：性类固醇对经典内分泌器官的增殖和凋亡具有戏剧性和差异性影响。在这项研究中，我们试图描绘性类固醇对淋巴细胞，T细胞和B细胞模型的增殖，细胞周期阶段和凋亡的类似作用。雌激素和睾丸激素抑制T细胞系增殖，诱导细胞周期的S / G（2）M阶段中的细胞积累，并以浓度和时间依赖性方式增加细胞凋亡。雌激素和睾丸激素对B淋巴细胞细胞系的细胞周期和凋亡的影响更为适度，这表明雌激素和睾丸激素对T细胞系具有抑制作用，但对B细胞系则无抑制作用。相比之下，黄体酮在T细胞和B细胞系中均诱导了细胞停滞并适度增加了细胞凋亡。雌激素和睾丸激素对细胞周期相分布的影响并不相互拮抗或没有协同作用，而对于细胞凋亡只有极小的协同作用。相反，孕酮拮抗细胞周期和雌激素在T细胞中的凋亡作用。雌激素诱导的细胞周期和T细胞株的凋亡效应与bcl-2蛋白水平的抑制有关，而bcl-2蛋白水平在Raji B细胞中不受影响。孕酮还拮抗雌激素诱导的T细胞bcl-2蛋白水平的变化。这些结果表明，对T和B淋巴细胞可能存在明显的和不同的性类固醇作用，这对于免疫和自身免疫反应中的性二分法可能很重要。版权所有2001 S. Karger AG，巴塞尔

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