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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Obesity associated with hypertension or hyperlipidemia accelerates renal damage.
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Obesity associated with hypertension or hyperlipidemia accelerates renal damage.

机译：与高血压或高脂血症相关的肥胖会加速肾脏损害。

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Obesity is known as a risk factor for nephropathy, especially nephrotic syndrome and focal segmental glomerulosclerosis, and can aggravate renal dysfunction. However, whether these changes are caused by obesity itself or by the associated hypertension (HT) and hyperlipidemia (HC) remains unclear at present. We investigated the influence of HT and HC in obesity on glomerular morphometry. The study included cases with obesity alone (O, body mass index more than 25 kg/m(2), n = 16), O+HC (n = 8), O+HT (n = 17), HC (n = 10) alone, HT (n = 7) alone, and normal subjects (N, n = 11). Renal biopsies were examined and the glomerular diameter, and length and diameter of the glomerular capillary loop were determined using image analysis software. Clinically related data were obtained from medical records at the time of biopsy. Obesity was associated with dilatation of glomerular diameter due to glomerular loop elongation. However, end-stage renal disease (ESRD) was not noted in patients with obesity only. In contrast, ESRD requiring hemodialysis was noted in group O+HT within a 7.7-year follow-up period. Furthermore, enlargement of loop diameter was noted in group O+HC, but not in HC alone. These results suggest that obesity alone may not result in glomerular hyperfiltration or renal dysfunction, but obesity associated with hypertension or hyperlipidemia may accelerate renal damage.
机译：肥胖是肾病的危险因素，尤其是肾病综合征和局灶性节段性肾小球硬化，可加重肾功能不全。但是，目前尚不清楚这些变化是由肥胖本身引起还是由相关的高血压（HT）和高脂血症（HC）引起的。我们调查了肥胖中的HT和HC对肾小球形态的影响。该研究包括仅患有肥胖症的患者（O，体重指数超过25 kg / m（2），n = 16），O + HC（n = 8），O + HT（n = 17），HC（n = 10），HT（n = 7）和正常人（N，n = 11）。检查肾脏活检，并使用图像分析软件确定肾小球直径，肾小球毛细血管loop的长度和直径。临床相关数据是从活检时的病历中获得的。肥胖与由于肾小球loop环伸长引起的肾小球直径扩张有关。但是，仅在肥胖患者中未发现晚期肾病（ESRD）。相比之下，O + HT组在7.7年的随访期内发现需要血液透析的ESRD。此外，在O + HC组中发现环直径增大，但在单独的HC中则没有。这些结果表明，单纯肥胖症可能不会导致肾小球高滤过或肾功能不全，但与高血压或高脂血症相关的肥胖症可能会加速肾脏损害。

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