• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Cytokeratin expression profiling in gastric carcinoma: Clinicopathologic significance and comparison with tumor-associated molecules
【24h】

Cytokeratin expression profiling in gastric carcinoma: Clinicopathologic significance and comparison with tumor-associated molecules

机译：胃癌中细胞角蛋白表达谱的临床病理意义及与肿瘤相关分子的比较

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: The expressions of cytokeratin (CK) 7 and 20 have been studied in various primary and metastatic carcinomas, and their determination may help distinguish the site of origin of metastatic carcinomas. However, little is known about the molecular basis that determines variations in CK patterns in gastric cancers (GCs). The aim of the present study was to analyze the CK expression patterns in a large number of GCs and to investigate how the CK patterns correlate with clinicopathologic parameters, histology, mucin phenotype or several tumor-related molecules. Methods and Results: We immunohistochemically examined the CK7/CK20 patterns, mucin expression profiles (MUC5AC, MUC6, MUC2 and CD10), and the cancer-related molecules (CDX2, p53, EGFR and β-catenin), using a tissue microarray with 870 GCs. The GCs were divided into four patterns; 17% of CK7+/CK20+, 57% of CK7+/CK20-, 9% of CK7-/CK20+ and 17% of CK7-/CK20. GCs with the CK7-/CK20- pattern demonstrated a close relation to undifferentiated adenocarcinoma. CK7 expression was significantly correlated with the expression of MUC5AC and MUC6, while CK20 expression was correlated with MUC2 and CDX2. There were statistically significant associations between CK expression patterns and mucin phenotypes. Conclusion: These results indicate that the CK7/CK20 expression patterns in GCs demonstrated different clinicopathologic features and molecular signatures.
机译：目的：研究细胞角蛋白（CK）7和20在各种原发性和转移性癌中的表达，其测定可能有助于区分转移性癌的起源部位。然而，对于决定胃癌（GCs）CK模式变化的分子基础知之甚少。本研究的目的是分析大量GC中的CK表达模式，并研究CK模式如何与临床病理参数，组织学，粘蛋白表型或几种肿瘤相关分子相关。方法和结果：我们使用具有870个组织的微阵列，通过免疫组织化学检查了CK7 / CK20模式，粘蛋白表达谱（MUC5AC，MUC6，MUC2和CD10）以及与癌症相关的分子（CDX2，p53，EGFR和β-catenin）。 GC。 GC分为四种模式： 17％的CK7 + / CK20 +，57％的CK7 + / CK20-，9％的CK7- / CK20 +和17％的CK7- / CK20。具有CK7- / CK20-模式的GC显示与未分化腺癌密切相关。 CK7的表达与MUC5AC和MUC6的表达显着相关，而CK20的表达与MUC2和CDX2的表达相关。在CK表达模式和粘蛋白表型之间存在统计学上的显着关联。结论：这些结果表明，GCs中的CK7 / CK20表达模式表现出不同的临床病理特征和分子特征。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号