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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Protective effects of 20(S)-protopanaxtriol on viral myocarditis infected by coxsackievirus B3
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Protective effects of 20(S)-protopanaxtriol on viral myocarditis infected by coxsackievirus B3

机译：20（S）-原萘三醇对柯萨奇病毒B3感染的病毒性心肌炎的保护作用

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Objective: Coxsackievirus B3 (CVB3) is a dominant causative agent for viral myocarditis. So far, effective therapies for the treatment of the disease are not available. 20(S)-Protopanaxtriol is a major component of Panax pseudoginseng and has been clinically used for the treatment of heart diseases. However, it is not known whether 20(S)-protopanaxtriol exerts any anti-viral effects. Thus, the aim of this study was to investigate the therapeutic effects of 20(S)-protopanaxtriol against CVB3 in vivo and in vitro. Methods: The antiviral effects of 20(S)-protopanaxtriol in vitro were evaluated in HeLa cells infected by CVB3. Then, we examined the protective effects of 20(S)-protopanaxtriol on CVB3-induced myocarditis in BALB/c mice. These mice were treated with 20(S)-protopanaxtriol at doses of 100-400 mg·kg -1·day -1 for 7 days and compared with the controls. Results: We found that 20(S)-protopanaxtriol possessed potent antiviral effects on CVB3 in vitro. Compared with control mice, virus titers and pathological changes in the hearts were significantly decreased in the 20(S)-protopanaxtriol- treated group. Furthermore, biochemical markers of myocardial injury such as plasma lactate dehydrogenase and creatine kinase were decreased to normal levels. Conclusions: These data provide the possibility that 20(S)-protopanaxtriol can be used as a potential therapeutic means for treatment of viral myocarditis.
机译：目的：柯萨奇病毒B3（CVB3）是病毒性心肌炎的主要病因。迄今为止，尚无用于治疗该疾病的有效疗法。 20（S）-普鲁他纳克斯三醇是人参的主要成分，已在临床上用于治疗心脏病。但是，尚不知道20（S）-原托那三醇是否发挥任何抗病毒作用。因此，本研究的目的是在体内和体外研究20（S）-原托那三醇对CVB3的治疗作用。方法：在被CVB3感染的HeLa细胞中评估了20（S）-异丙氧萘酚的体外抗病毒作用。然后，我们检查了20（S）-原托那那三醇对CVB3诱导的BALB / c小鼠心肌炎的保护作用。将这些小鼠用20（S）-异丙氧萘酚以100-400 mg·kg -1·day -1的剂量处理7天，并与对照组进行比较。结果：我们发现20（S）-原萘三醇在体外对CVB3具有强大的抗病毒作用。与对照小鼠相比，在20（S）-原托那三醇治疗组中，病毒滴度和心脏的病理变化明显降低。此外，心肌损伤的生化指标，例如血浆乳酸脱氢酶和肌酸激酶降低到正常水平。结论：这些数据提供了将20（S）-原托那三醇用作病毒性心肌炎的潜在治疗手段的可能性。

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