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首页> 外文期刊>Parasite Immunology >Immunomodulatory effects of helminths and protozoa in multiple sclerosis and experimental autoimmune encephalomyelitis.
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Immunomodulatory effects of helminths and protozoa in multiple sclerosis and experimental autoimmune encephalomyelitis.

机译：蠕虫和原生动物在多发性硬化症和实验性自身免疫性脑脊髓炎中的免疫调节作用。

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Multiple sclerosis is a chronic inflammatory CNS disease, which affects about 1 in 1000 individuals in the western world. During the last couple of decades, epidemiological data have accumulated, pointing towards increases in incidence. This has been suggested to be linked to the relatively high hygiene standards that exist in the western world, with reduced exposure to various pathogens, including parasites, as a consequence. Parasites are known to employ various immunomodulatory and anti-inflammatory strategies, which enable them to evade destruction by the immune system. This is most likely one of the reasons for the disease-dampening effects, reported in numerous studies investigating parasite infections and autoimmunity. This review will focus on recent advances in the field of parasites as beneficial immunomodulators, in multiple sclerosis and the animal model experimental autoimmune encephalomyelitis.Digital Object Identifier http://dx.doi.org/10.1111/pim.12023
机译：多发性硬化症是一种慢性炎症性中枢神经系统疾病，在西方世界影响约千分之一的人。在过去的几十年中，流行病学数据已经积累，表明发病率在增加。有人认为这与西方世界相对较高的卫生标准有关，因此减少了对包括寄生虫在内的各种病原体的接触。已知寄生虫采用各种免疫调节和抗炎策略，使它们能够逃避免疫系统的破坏。这是最有可能抑制疾病的原因之一，在许多研究寄生虫感染和自身免疫的研究中都有报道。这项审查将侧重于寄生虫作为有益的免疫调节剂，多发性硬化症和动物模型实验性自身免疫性脑脊髓炎领域的最新进展。数字对象标识符http://dx.doi.org/10.1111/pim.12023

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