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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >P16-immunostaining pattern as a predictive marker of lymph node metastasis and recurrence in early uterine cervical cancer.
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P16-immunostaining pattern as a predictive marker of lymph node metastasis and recurrence in early uterine cervical cancer.

机译：P16免疫染色模式可作为早期子宫颈癌淋巴结转移和复发的预测指标。

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OBJECTIVES: We investigated the relationship between P16-immunostaining patterns and clinicopathological factors in early uterine cervix cancers and assessed whether P16-immunostaining patterns predict the prognosis of the patients with early uterine cervix cancers. METHODS: Twenty-nine early squamous cell carcinoma (SCC) specimens of the uterus were examined using immunohistochemistry for P16 expression. The P16-immunostaining pattern was classified into two groups: the homogeneous type and the heterogeneous type. P16-immunostaining patterns were evaluated in different parts of the carcinoma in situ (CIS): the center of the tumor and the front interface of the infiltrating tumor. RESULTS: All specimens were of the homogeneous type in CIS. The P16-immunostaining pattern was significantly of the heterogeneous type in the front interface of the infiltrating tumor with lymphatic invasion, vascular invasion, lymph node metastasis, and recurrence. Regarding the P16-immunostaining patterns in the front interface of the infiltrating tumor, the patients with the heterogeneous type showed a significantly worse prognosis than the patients with the homogeneous type. CONCLUSIONS: The prognosis of patients with early uterine cervical SCC may be predicted by evaluating the P16-immunostaining pattern in the front interface of the infiltrating tumor.
机译：目的：我们调查了早期宫颈癌中P16免疫染色模式与临床病理因素之间的关系，并评估了P16免疫染色模式是否可以预测早期宫颈癌患者的预后。方法：采用免疫组织化学方法检测了29例子宫早期鳞状细胞癌（SCC）标本的P16表达。 P16免疫染色模式分为两类：同质型和异质型。在原位癌（CIS）的不同部位（肿瘤的中心和浸润的肿瘤的前界面）评估了P16免疫染色模式。结果：所有样本均为独联体均质型。 P16免疫染色模式在浸润性肿瘤的前界面具有明显的异质性类型，伴有淋巴管浸润，血管浸润，淋巴结转移和复发。关于浸润性肿瘤的前界面中的P16免疫染色模式，异质型患者的预后显着低于同质型患者。结论：可通过评估浸润性肿瘤前界面的P16免疫染色模式来预测早期子宫宫颈鳞癌的预后。

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