Microwave-induced structural and functional injury of hippocampal and PC12 cells is accompanied by abnormal changes in the NMDAR-PSD95-CaMKII pathway

LaboratoryofExperimentalPathologyBeijingInstituteofRadiationMedicine; LaboratoryofRadiationProtectionBeijingInstituteofRadiationMedicine; DepartmentofPathologyBeijingTongrenHospital

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Microwave-induced structural and functional injury of hippocampal and PC12 cells is accompanied by abnormal changes in the NMDAR-PSD95-CaMKII pathway

机译：微波诱导的海马和PC12细胞的结构和功能损伤伴有NMDAR-PSD95-CaMKII途径的异常变化

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Recent studies have highlighted the important role of the postsynaptic NMDAR-PSD95-CaMKII pathway for synaptic transmission and related neuronal injury. Here, we tested changes in the components of this pathway upon microwave-induced neuronal structure and function impairments. Ultrastructural and functional changes were induced in hippocampal neurons of rats and in PC12 cells exposed to microwave radiation. We detected abnormal protein and mRNA expression, as well as posttranslational modifications in the NMDAR-PSD95-CaMKII pathway and its associated components, such as synapsin I, following microwave radiation exposure of rats and PC12 cells. Thus, microwave radiation may induce neuronal injury via changes in the molecular organization of postsynaptic density and modulation of the biochemical cascade that potentiates synaptic transmission.

机译：最近的研究突出了突触后NMDAR-PSD95-CaMKII通路在突触传递和相关神经元损伤中的重要作用。在这里，我们测试了微波诱导的神经元结构和功能受损后，该途径成分的变化。在大鼠海马神经元和暴露于微波辐射的PC12细胞中诱导了超微结构和功能的变化。在大鼠和PC12细胞受到微波辐射后，我们检测到蛋白质和mRNA表达异常，以及NMDAR-PSD95-CaMKII途径及其相关成分（如突触蛋白I）的翻译后修饰。因此，微波辐射可能通过改变突触后密度的分子组织和增强突触传递的生化级联反应而引起神经元损伤。

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《Pathobiology: journal of immunopathology, molecular and cellular biology》 |2015年第5期|共14页
作者
LaboratoryofExperimentalPathologyBeijingInstituteofRadiationMedicine; LaboratoryofRadiationProtectionBeijingInstituteofRadiationMedicine; DepartmentofPathologyBeijingTongrenHospital;
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正文语种 eng
中图分类病理学;
关键词
CaMKII; Microwave; NMDARs; PSD95; Synapsin I;

机译：CaMKII;微波;NMDARs;PSD95;突触素I;

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1. Microwave-induced structural and functional injury of hippocampal and PC12 cells is accompanied by abnormal changes in the NMDAR-PSD95-CaMKII pathway [J] . LaboratoryofExperimentalPathologyBeijingInstituteofRadiationMedicine, LaboratoryofRadiationProtectionBeijingInstituteofRadiationMedicine, DepartmentofPathologyBeijingTongrenHospital Pathobiology: journal of immunopathology, molecular and cellular biology . 2015,第5期

机译：微波诱导的海马和PC12细胞的结构和功能损伤伴有NMDAR-PSD95-CaMKII途径的异常变化
2. Upregulation of HIF-1 alpha Via Activation of ERK and PI3K Pathway Mediated Protective Response to Microwave-Induced Mitochondrial Injury in Neuron-Like Cells [J] . Zhao Li, Yang Yue-Feng, Gao Ya-Bing, Molecular Neurobiology . 2014,第3期

机译：通过激活ERK和PI3K途径介导的对神经元样细胞微波诱导的线粒体损伤的保护反应，通过激活HIF-1 alpha上调。
3. Hippocampal cell loss and propagation of abnormal discharges accompanied with the expression of tonic convulsion in the spontaneously epileptic rat. [J] . Hanaya R, Sasa M, Sugata S, Brain research . 2010,第Null期

机译：自发性癫痫大鼠海马细胞丢失，异常放电的传播以及强直性惊厥的表达。
4. Effects of low-intensity pulsed ultrasound on nerve growth factor-induced neurite outgrowth mainly through ERK-CREB pathway in PC12 cells [C] . Lu Zhao, Yi Feng, Hong Hu, IEEE International Ultrasonics Symposium . 2015

机译：低强度脉冲超声主要通过PC12细胞中的ERK-CREB途径对神经生长因子诱导的神经突生长的影响
5. Apoptotic cell death in neuronal PC12 cells and cortical neurons: Converging pathways through cGMP and the inhibition of cell cycle [D] . Wirtz-Brugger, Friederike 2000

机译：神经元PC12细胞和皮质神经元的凋亡细胞死亡：通过cGMP的融合途径和细胞周期抑制
6. Functional structural and metabolic abnormalities of the hippocampal formation in Williams syndrome [O] . Andreas Meyer-Lindenberg, Carolyn B. Mervis, Deepak Sarpal, 2005

机译：海马的功能结构和代谢异常威廉姆斯综合征的形成
7. Microwave-Induced Structural and Functional Injury of Hippocampal and PC12 Cells Is Accompanied by Abnormal Changes in the NMDAR-PSD95-CaMKII Pathway [O] . Li-Feng Wang, Li Wei, Si-Mo Qiao, 2015

机译：微波诱导的海马和PC12细胞的结构和功能损伤伴随着NMDAR-PSD95-CAMKII途径的异常变化
8. Leukemic Reticuloendotheliosis: 'Hairy Cell Leukemia,' Functional and Structural Features of the Abnormal Cell in a Patient with Profound Leukocytosis. [R] . Boldt, D. H., Speckart, S. F., MacDermott, R. P., 1976

机译：白血病网状内皮增生症：“毛细胞白血病”，患有深部白细胞增多症的患者异常细胞的功能和结构特征。

Microwave-induced structural and functional injury of hippocampal and PC12 cells is accompanied by abnormal changes in the NMDAR-PSD95-CaMKII pathway

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