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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Antisense phosphorothioate oligodeoxynucleic acid for CD10 suppresses liver metastasis of colorectal cancer.
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Antisense phosphorothioate oligodeoxynucleic acid for CD10 suppresses liver metastasis of colorectal cancer.

机译：用于CD10的反义硫代磷酸酯寡聚脱氧核酸抑制大肠癌的肝转移。

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摘要

CD10 expression is associated with metastases of colorectal cancer (CRC). In the present study, we examined association of CD10 with liver metastasis of CRC cells to clarify the therapeutic significance of CD10. CD10-positive human colon cancer cell line, HT29 cells showed inhibition of growth, invasion and colony formation by treatment with CD10 antisense S-oligodeoxynucleotide (S-ODN). In the mouse liver metastasis mode, CD10 antisense S-ODN-treated HT29 cells made less embedded cells in the liver than control HT29 cells. Number and size of metastatic foci in nude mice liver were reduced in CD10 antisense S-ODN-treated HT29 cells. Treatment with CD10 antisense S-ODN decreased phosphorylation of ERK1/2 and EGFR in HT29 cells. Intraperitoneal administration of liposome-capsulated CD10 antisense S-ODN inhibited establishment of liver metastasis and growth of established metastasis in nude mice. These findings suggest that CD10 is associated substantially with liver metastasis of CRC cells and might be a molecular target of CRC treatment.
机译：CD10表达与结直肠癌（CRC）的转移有关。在本研究中，我们检查了CD10与CRC细胞肝转移的关系，以阐明CD10的治疗意义。 CD10阳性人结肠癌细胞系HT29细胞通过用CD10反义S-寡脱氧核苷酸（S-ODN）处理，显示出生长，侵袭和集落形成的抑制作用。在小鼠肝转移模式中，经CD10反义S-ODN处理的HT29细胞在肝脏中的包埋细胞少于对照HT29细胞。在CD10反义S-ODN处理的HT29细胞中，裸鼠肝脏中转移灶的数量和大小减少。用CD10反义S-ODN处理可降低HT29细胞中ERK1 / 2和EGFR的磷酸化。脂质体包裹的CD10反义S-ODN的腹膜内给药可抑制裸鼠体内肝转移的建立和转移的生长。这些发现表明，CD10与CRC细胞的肝转移基本相关，并且可能是CRC治疗的分子靶标。

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