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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Ischemic damage and subsequent proliferation of oligodendrocytes in hippocampal CA1 region following repeated brief cerebral ischemia.
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Ischemic damage and subsequent proliferation of oligodendrocytes in hippocampal CA1 region following repeated brief cerebral ischemia.

机译：反复短暂性脑缺血后，海马CA1区的少突胶质细胞缺血性损害和随后的增殖。

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摘要

Changes in oligodendrocytes and astrocytes following repeated brief periods of ischemia were studied in gerbils. The repeated brief periods of cerebral ischemia were produced by occlusion of bilateral common arteries for 3 x 3 min at 1-hour intervals. Oligodendrocytes and astrocytes in hippocampal CA1 regions were examined on 1, 3, 7 and 14 days after ischemia. Seven days after ischemia reperfusion, astrocytes, large pale and small dark oligodendrocytes entered the necrotic pyramidal neuron layer and coexisted with microglia. The necrotic matter of neurons and phagolysosome was observed in cytoplasm of some large pale and small dark oligodendrocytes. Most oligodendrocytes also intermingled with reactive astrocytes. These reactive astrocytes showed glial fibrillary acidic protein-positive reaction. Furthermore, proliferating cell nuclear antigen-positive cells increased markedly 7 days after reperfusion. We conclude that the repeated brief cerebral ischemia caused proliferation of oligodendrocytes and astrocytes, and oligodendrocytes may play a phagocytic role for clearance of necrotic matter of neurons.
机译：在沙鼠中研究了短暂反复缺血后少突胶质细胞和星形胶质细胞的变化。通过每隔1小时间隔双侧共同动脉阻塞3 x 3分钟来产生反复短暂的脑缺血。在缺血后1、3、7和14天检查海马CA1区的少突胶质细胞和星形胶质细胞。缺血再灌注7天后，星形胶质细胞，大的苍白和小的暗少突胶质细胞进入坏死的锥体神经元层并与小胶质细胞共存。在一些较大的浅色和小的深色少突胶质细胞的细胞质中观察到了神经元和吞噬溶酶体的坏死物质。大多数少突胶质细胞也与反应性星形胶质细胞混合。这些反应性星形胶质细胞显示神经胶质纤维酸性蛋白阳性反应。此外，再灌注后7天，增殖细胞核抗原阳性细胞明显增加。我们得出的结论是反复短暂的脑缺血导致少突胶质细胞和星形胶质细胞的增殖，并且少突胶质细胞可能在清除神经元坏死物质中起吞噬作用。

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