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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Glutathione and ascorbic acid enhance recovery of Guinea pig spinal cord white matter following ischemia and acrolein exposure.
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Glutathione and ascorbic acid enhance recovery of Guinea pig spinal cord white matter following ischemia and acrolein exposure.

机译：谷胱甘肽和抗坏血酸增强缺血和丙烯醛暴露后豚鼠脊髓白质的恢复。

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OBJECTIVE: We have shown that acrolein, a lipid peroxidation byproduct, can inflict significant damage in isolated spinal cord white matter following oxygen glucose deprivation (OGD). The mechanism of such acrolein-induced damage is unclear. The aim of this study was to examine whether glutathione (GSH) and ascorbic acid, two reactive oxygen species (ROS) scavengers, can alleviate functional and anatomical damage due to acrolein. METHODS: We used an OGD injury model with isolated guinea pig spinal cord white matter. Sucrose gap recording was used to monitor axonal impulse conduction, and a horseradish peroxidase exclusion test was employed to determine membrane integrity. The functional and anatomical parameters were compared in three groups: acrolein, acrolein/GSH and acrolein/ascorbic acid. RESULTS: We found that while GSH resulted in an 87% recovery of compound action potential conductance, ascorbic acid produced a 97% recovery, compared with a 69% recovery in an injured group without treatment. It is noted that GSH, and to a lesser extent ascorbic acid, preferentially enhanced functional recovery in smaller axons. CONCLUSION: Acrolein-induced neuronal damage is likely mediated by ROS. Furthermore, GSH and ascorbic acid are effective in suppressing acrolein and free radical-induced injury in spinal cord white matter.
机译：目的：我们已经表明，脂质过氧化副产物丙烯醛会在氧葡萄糖剥夺（OGD）后对孤立的脊髓白质造成重大损害。这种丙烯醛引起的损伤的机制尚不清楚。这项研究的目的是检查谷胱甘肽（GSH）和抗坏血酸（两种活性氧（ROS）清除剂）是否可以减轻丙烯醛对功能和解剖的损害。方法：我们使用了豚鼠脊髓白质分离的OGD损伤模型。蔗糖间隙记录用于监测轴突脉冲传导，辣根过氧化物酶排阻测试用于确定膜完整性。在三组中比较了功能和解剖参数：丙烯醛，丙烯醛/ GSH和丙烯醛/抗坏血酸。结果：我们发现，虽然GSH可使复合动作电位电导恢复87％，但抗坏血酸可恢复97％，而未经治疗的受伤组可恢复69％。应当指出，谷胱甘肽和较小程度的抗坏血酸优先增强了较小轴突的功能恢复。结论：丙烯醛诱导的神经元损伤可能是由R​​OS介导的。此外，GSH和抗坏血酸可有效抑制丙烯醛和自由基引起的脊髓白质损伤。

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