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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Loss of heterozygosity on chromosome 10p14-p15 in colorectal carcinoma.
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Loss of heterozygosity on chromosome 10p14-p15 in colorectal carcinoma.

机译：大肠癌10p14-p15染色体杂合性的丧失。

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摘要

High frequencies of loss of heterozygosity (LOH) on chromosome 10p14-p15 have been reported in various tumors, including gliomas, pulmonary carcinoid tumors and cervical, hepatic, prostatic and esophageal carcinomas. However, LOH on chromosome 10p14-p15 in colorectal tumors has not been reported. Therefore, we examined LOH on chromosome 10p14-p15 in 60 colorectal carcinomas (21 superficial and 39 advanced types) by microsatellite assay. Three microsatellite loci, D10S191 (10p14), D10S558 and D10S249 (10p15) were examined by polymerase chain reaction [early colorectal carcinomas, LOH of markers D10S191 (36%), D10S558 (7%) and D10S249 (11%), and in advanced colorectal carcinomas, LOH of markers D10S191 (20%), D10S558 (13%) and D10S249 (33%)]. There were no significant associations between LOH on chromosome 10p14-p15 and clinicopathologic features, including patient age, sex, tumor location, depth of invasion, histologic type, lymph node metastasis and prognosis. These data suggest that a putative tumor suppressor gene associated with colorectal carcinogenesis may be located on chromosome 10p14-p15 and that alteration of this gene may be involved in the development but not progression of colorectal tumors.
机译：据报道，在10p14-p15染色体上高频率的杂合子缺失（LOH）在各种肿瘤中都有报道，包括神经胶质瘤，肺类癌和宫颈癌，肝癌，前列腺癌和食道癌。然而，尚未报道大肠肿瘤中染色体10p14-p15上的LOH。因此，我们通过微卫星分析检测了60例大肠癌（21种浅表和39种晚期类型）的10p14-p15染色体上的LOH。通过聚合酶链反应检查了三个微卫星基因座，D10S191（10p14），D10S558和D10S249（10p15）[早期大肠癌，标志物D10S191的LOH（36％），D10S558（7％）和D10S249（11％），并且处于晚期大肠癌，标志物D10S191（20％），D10S558（13％）和D10S249（33％）的LOH]]。 10p14-p15染色体上的LOH与临床病理特征（包括患者年龄，性别，肿瘤位置，浸润深度，组织学类型，淋巴结转移和预后）之间无显着关联。这些数据表明与结肠直肠癌发生有关的推定的抑癌基因可能位于染色体10p14-p15上，并且该基因的改变可能与结肠直肠肿瘤的发生有关，而与结肠直肠肿瘤的进展无关。

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