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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >The expression pattern of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetyl-galactosaminyl transferase-3 in squamous cell carcinoma of the esophagus.
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The expression pattern of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetyl-galactosaminyl transferase-3 in squamous cell carcinoma of the esophagus.

机译：UDP-N-乙酰基-α-D-半乳糖胺-多肽N-乙酰基-半乳糖胺基转移酶3在食管鳞状细胞癌中的表达模式。

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OBJECTIVE: UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyl transferase-3 (GalNAc-T3) regulates the initial glycosylation of mucin-type O-linked proteins. Although a different expression of GalNAc-T3 has been reported in various cancers, the expression has not been characterized in squamous cell carcinoma (SCC) of the esophagus. METHODS: We have also evaluated the expression of this enzyme in surgically resected esophageal mucosa. By immunohistochemical staining using a specific antibody, we evaluated the expression of GalNAc-T3 in 66 esophageal SCC and 28 dysplasia samples, and analyzed the relationship between the expression of GalNAc-T3 and clinicopathological features. RESULTS: GalNAc-T3 was positively detected in the majority of the cases of SCC, but not in dysplasia as well as the normal counterparts in resected esophagus. GalNAc-T3 was determined to be positive in 37 cases (68.5%) of differentiated carcinomas, but only in 4 cases (33.3%) of undifferentiated carcinomas (p < 0.05). Hematogeneous metastasis was observed in 13 of 41 (31.7%) GalNAc-T3-positive tumors, which was significantly more frequent than in negative tumors (2/25, 8%; p < 0.05). The number of metastatic nodes was significantly higher in tumors with GalNAc-T3-positive than GalNAc-negative expression (4.2 +/- 3.2 vs. 2.8 +/- 1.3, p < 0.05). The survival rate tended to be lower for patients with GalNAc-T3-positive tumors, although the difference was not statistically significant (p = 0.18). CONCLUSION: GalNAc-T3 may play a positive role in the process of carcinogenesis and progression in esophageal SCC. Functional inhibition of GalNAc-T3 may be effective for the prevention and treatment of esophageal SCC.
机译：目的：UDP-N-乙酰基-α-D-半乳糖胺-多肽N-乙酰基半乳糖胺基转移酶3（GalNAc-T3）调节粘蛋白O型连接蛋白的初始糖基化。尽管在各种癌症中已报道了GalNAc-T3的不同表达，但在食道鳞状细胞癌（SCC）中尚未对该表达进行表征。方法：我们还评估了该酶在手术切除的食管粘膜中的表达。通过使用特异性抗体的免疫组织化学染色，我们评估了GalNAc-T3在66例食管SCC和28个不典型增生样本中的表达，并分析了GalNAc-T3的表达与临床病理特征之间的关系。结果：在大多数SCC病例中，GalNAc-T3阳性，但在不典型增生中和切除的食管中的正常对应物中均未检出。 GalNAc-T3在37例（68.5％）的分化癌中被确定为阳性，但在4例（33.3％）的未分化癌中被确定为阳性（p <0.05）。在41个（31.7％）GalNAc-T3阳性肿瘤中，有13个发生了血源性转移，其发生率明显高于阴性肿瘤（2/25，8％; p <0.05）。 GalNAc-T3阳性表达的肿瘤中转移结点的数量明显高于GalNAc阴性表达的肿瘤（4.2 +/- 3.2 vs. 2.8 +/- 1.3，p <0.05）。 GalNAc-T3阳性肿瘤患者的生存率往往较低，尽管差异无统计学意义（p = 0.18）。结论：GalNAc-T3可能在食管鳞癌的发生，发展过程中起积极作用。 GalNAc-T3的功能抑制可能有效预防和治疗食道SCC。

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