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Clinical impact and biomaterial evaluation of autologous platelet gel in cardiac surgery.

机译:自体血小板凝胶在心脏手术中的临床影响和生物材料评估。

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摘要

We compared the clinical efficacy of autologous platelet gel (APG) and gelatine (CONT), including biomaterial evaluation. In a prospective, randomized, controlled trial, 64 patients undergoing complex coronary artery bypass graft (CABG) surgery and/or aortic surgery, in whom the surgeon was able to identify a bleeding site for which conventional means to stop bleeding were impractical or proved unsuccessful, were enrolled. Aortic punch biopsy from each patient was harvested in explant cell (EC) culture media. Hemostasis success for the "oozing" category was 89% in APG and 60% in CONT (p< 0.05). For the "heavy bleeding" category, the success rates were 92% in APG and 45% in CONT (p<0.01). Contact of gelatine inhibited EC proliferation and APG increased cell cycling and EC quantity. Phagocytic capacity (PC) was significantly higher in the APG group (p<0.001). APG was significantly better than CONT with respect to hemostatic success rate, effects on wound healing and increased resistance to infection (PC).
机译:我们比较了自体血小板凝胶(APG)和明胶(CONT)的临床疗效,包括生物材料评估。在一项前瞻性,随机,对照试验中,有64位患者接受了复杂的冠状动脉搭桥术(CABG)手术和/或主动脉手术,其中外科医生能够确定常规的止血方法不可行或证明不成功的出血部位,已被注册。在外植细胞(EC)培养基中收获每个患者的主动脉穿孔活检。 “渗出”类别的止血成功率在APG中为89%,在CONT中为60%(p <0.05)。对于“重度出血”类别,APG的成功率为92%,CONT的成功率为45%(p <0.01)。明胶的接触抑制了EC的增殖,APG增加了细胞周期和EC的数量。 APG组的吞噬能力(PC)明显更高(p <0.001)。在止血成功率,对伤口愈合的影响和增加的抗感染性(PC)方面,APG明显优于CONT。

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