...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pest Management Science >Design, synthesis and insecticidal activities of novel pyrazole amides containing hydrazone substructures
【24h】

Design, synthesis and insecticidal activities of novel pyrazole amides containing hydrazone substructures

机译：含sub亚结构的新型吡唑酰胺的设计，合成和杀虫活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Pyrazole and hydrazone derivatives possess good insecticidal activities; their substructural units are widely used in pesticide design. In an effort to discover new molecules with good insecticidal activities, a series of pyrazole amide derivatives containing hydrazone substructures were synthesised and bioassayed.RESULTS: Bioassays demonstrated that some of the title compounds exhibited notable control of Plutella xylostella (Linnaeus), Helicoverpa armigera (Hubner), Culex pipiens pallens, Laphygma exigua (Hubner), Spodoptera litura (Fabricius), Nilaparvata lugens (Stal) and Rhopalosiphum maidis (Fitch) at 5,10,0.25,200, 20,100 and 500 mg L~(-1) respectively. Comparative molecular field analysis (CoMFA) based on the bioactlvities for P. xylostella was studied; the values of q~2 and r~2 for the CoMFA model were 0.701 and 0.964 respectively.CONCLUSION: Some of the title compounds displayed good and broad-spectrum insecticidal activities against different Insect species; the CoiVIFA model revealed that a bulky and negatively charged group at the 4-posltlon of benzene could enhance insecticidal activity. These results could provide useful Information for the design of novel insecticide containing substructural units of pyrazole amide and hydrazone.
机译：背景：吡唑和衍生物具有良好的杀虫活性。它们的子结构单元广泛用于农药设计中。为了发现具有良好杀虫活性的新分子，合成了一系列含有亚结构的吡唑酰胺衍生物并对其进行了生物分析。 ），淡色库蚊（Culex pipiens pallens），拉菲藻（Hubner），斜纹夜蛾（Fabodius），褐飞虱（Nilaparvata lugens）（Stal）和红景天（Fitch）分别为5,10,0.25,200、20,100和500 mg L〜（-1）。研究了基于生物活性的小菜蛾的比较分子场分析（CoMFA）。结论：某些标题化合物对不同种类的昆虫表现出良好的杀虫活性和广谱杀虫活性; CoMFA模型的q〜2和r〜2值分别为0.701和0.964。 CoiVIFA模型显示，苯的4-posltlon上的一个庞大且带负电荷的基团可以增强杀虫活性。这些结果可为设计新型含吡唑酰胺和亚结构单元的杀虫剂提供有用的信息。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号