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首页> 外文期刊>Pfluegers Archiv: European Journal of Physiology >Hepatic arterial perfusion regulates portal venous flow between hepatic sinusoids and intrahepatic shunts in the normal rat liver in vitro.
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Hepatic arterial perfusion regulates portal venous flow between hepatic sinusoids and intrahepatic shunts in the normal rat liver in vitro.

机译：在正常大鼠肝脏中，肝动脉灌注可调节肝窦和肝内分流之间的门静脉流动。

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摘要

Intrahepatic shunts regulate portal venous pressure during periods of acute portal hypertension when the transhepatic portal resistance is momentarily increased in the normal rat liver in vivo. Hepatic arterial inflow may also increase the transhepatic portal resistance and activate intrahepatic shunts. In the present study, the transhepatic portal resistance and the activity of intra-hepatic shunts were measured in vitro and the point of confluence between the hepatic artery and portal vein in the rat determined. Livers of male Sprague-Dawley rats were single-pass, dual-perfused in vitro. Total cessation or diversion of the hepatic arterial inflow to the portal venous vasculature, whilst maintaining total hepatic perfusate flow, decreased intrasinusoidal pressure, increased transhepatic portal venous resistance and opened the portal venous intrahepatic shunts in a manner similar to intraportal injection of 15-microm diameter microspheres. Injections of the microspheres into the hepatic arterial circulation increased hepatic arterial pressure dramatically, consistent with complete occlusion of the arterial vasculature. The intrahepatic shunts are located at a pre-sinusoidal level because no increases were detected in hepatic arterial pressure following intraportal injection of microspheres. The hepatic arterial vasculature, unlike the portal supply, does not possess a collateral shunt circulation and coalesces with the portal vein at an intrasinusoidal location
机译：肝门内分流在急性门静脉高压症期间调节门静脉压力，而在正常大鼠肝脏中，经肝门静脉阻力暂时升高。肝动脉流入也可能增加跨肝门静脉阻力并激活肝内分流。在本研究中，在体外测量了跨肝门静脉阻力和肝内分流的活性，并确定了大鼠肝动脉和门静脉之间的汇合点。雄性Sprague-Dawley大鼠的肝脏在体外进行单次，两次灌注。完全停止或转移进入门静脉血管的肝动脉血流，同时保持总肝灌注液流量，降低的窦内压力，增加肝门静脉阻力，并以类似于门静脉内注射15微米直径的方式打开门静脉肝内分流管微球。将微球注射入肝动脉循环可显着增加肝动脉压力，这与动脉血管系统的完全闭塞相一致。肝内分流位于正弦前水平，因为在门静脉内注射微球后未检测到肝动脉压升高。与门脉供血不同，肝动脉脉管系统不具有侧支循环，在门脉窦内与门静脉融合

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