SYNTHESIS AND BIOLOGICAL ACTIVITY OF NEW PYRANOCHRQMEN-3-CARBOXAMIDES

R. V. Shutov; 1 E. V. Kuklina; 1 N. A. Anisimova; 1 E. P. Ananev; N. I. Kotova; 1 V. N. Kuklin

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SYNTHESIS AND BIOLOGICAL ACTIVITY OF NEW PYRANOCHRQMEN-3-CARBOXAMIDES

机译：新型拟南芥3-羧酰胺的合成及生物活性

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A series of new pyranochromen-3-carboxamides have been synthesized in good yield by reacting 2-phenyl-4-hydroxy-6H-l,3-thiazin-6-ones with substituted 3-formylchromones. Pharmacological screening showed an influence of the substituent in the 9-position of the pyranochromen-3-carboxamides on the acute toxicity and antifungal, analgesic, and anxiolytic activity. 9-Bromo-2H,5H-pyranochromen-3-carboxamide can be recommended for farther pharmacological investigation.

机译：通过使2-苯基-4-羟基-6H-1，3-噻嗪-6-酮与取代的3-甲酰基色酮反应，以高收率合成了一系列新的吡喃色素-3-羧酰胺。药理筛选显示吡喃色素-3-羧酰胺的9位取代基对急性毒性和抗真菌，止痛和抗焦虑活性有影响。推荐9-Bromo-2H，5H-吡喃色素n-3-羧酰胺用于进一步的药理研究。

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《Pharmaceutical Chemistry Journal》 |2012年第1期|共5页
作者
R. V. Shutov; 1 E. V. Kuklina; 1 N. A. Anisimova; 1 E. P. Ananev; N. I. Kotova; 1 V. N. Kuklin;
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正文语种 eng
中图分类药学;
关键词
pyranochromen-3-carboxamides; 3-formylchromones; synthesis; structure; analgesic; anxiolytic; and antimicrobial activity.;

机译：吡喃铬-3-甲酰胺;3-甲酰基色酮;合成;结构;止痛;抗焦虑和抗菌活性;

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1. SYNTHESIS AND BIOLOGICAL ACTIVITY OF NEW PYRANOCHRQMEN-3-CARBOXAMIDES [J] . R. V. Shutov, 1 E. V. Kuklina, 1 N. A. Anisimova, Pharmaceutical Chemistry Journal . 2012,第1期

机译：新型拟南芥3-羧酰胺的合成及生物活性
2. Derivatives of Isoindoline, Synthesis and Biological Activity. II. Biological Activity of Isoindoline Derivatives [J] . I. Sovi?, G. Karminski-Zamola Kemija u industriji . 2014,第03a04期

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SYNTHESIS AND BIOLOGICAL ACTIVITY OF NEW PYRANOCHRQMEN-3-CARBOXAMIDES

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