Derivatives of Isoindoline, Synthesis and Biological Activity. II. Biological Activity of Isoindoline Derivatives

I. Sovi?; G. Karminski-Zamola

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Derivatives of Isoindoline, Synthesis and Biological Activity. II. Biological Activity of Isoindoline Derivatives

机译：异吲哚啉的衍生物，合成和生物活性。二。异吲哚啉衍生物的生物活性

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The derivatives of isoindolines show different biological activity in vitro and in vivo and it is hopefulthat some of the compounds of this group will develop into new efficient drugs for differenttypes of diseases in the future. They are present in many natural and synthetic, biologically activecompounds, which have been reported to possess psycho-stimulant, analgesic, anti-inflammatory,antipyretic, antihypertensive, antifungal, and antitumor properties. Metal complexes of isondolinederivatives act as inhibitors of protein kinase and catalase. Among different biological activity,isoindoline derivatives also show activity against tumor cells of leukemia and are active on colon,epidermal and ovarian cancer. They also inhibit a number of enzymes responsible for cancercell reproduction, such as histone deacetylase, tyrosine kinase receptor, and vascular endothelialgrowth factor receptor (VEGF-R2).

机译：异吲哚啉的衍生物在体内和体外表现出不同的生物学活性，希望这一类化合物中的某些将来能发展成为用于不同类型疾病的新型有效药物。它们存在于许多天然和合成的生物活性化合物中，据报道它们具有心理刺激，镇痛，抗炎，解热，抗高血压，抗真菌和抗肿瘤特性。异吲哚啉衍生物的金属络合物充当蛋白激酶和过氧化氢酶的抑制剂。在不同的生物学活性中，异吲哚啉衍生物还显示出对白血病肿瘤细胞的活性，并且对结肠癌，表皮癌和卵巢癌具有活性。它们还抑制许多引起癌细胞繁殖的酶，例如组蛋白脱乙酰基酶，酪氨酸激酶受体和血管内皮生长因子受体（VEGF-R2）。

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《Kemija u industriji》 |2014年第04期|共9页
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I. Sovi?; G. Karminski-Zamola;
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1. Derivatives of Isoindoline, Synthesis and Biological Activity. I. Natural and Synthetic Isoindoline Derivatives [J] . I. Sovi?, G. Karminski-Zamola Kemija u industriji . 2014,第03a04期

机译：异吲哚啉的衍生物，合成和生物活性。 I.天然和合成的异吲哚啉衍生物
2. Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents [J] . Dawid Panek, Anna Wi?ckowska, Anna Pasieka, Molecules . 2018,第2期

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机译：合成，表征一些含有1,3,4-二唑和1,3,4-噻二唑部分的一些新的L，3-氧嗪-4-一种衍生物，其具有筛选其一些生物活性。
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7. Derivatives of Isoindoline, Synthesis and Biological Activity. II. Biological Activity of Derivatives of Isoindoline [O] . Sović, I., Karminski-Zamola, G. 2014

机译：异吲哚啉的衍生物，合成和生物活性。二。异吲哚啉衍生物的生物活性

Derivatives of Isoindoline, Synthesis and Biological Activity. II. Biological Activity of Isoindoline Derivatives

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