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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Fetal ethanol effects on benzodiazepine sensitivity measured by behavior on the elevated plus-maze.
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Fetal ethanol effects on benzodiazepine sensitivity measured by behavior on the elevated plus-maze.

机译：胎儿乙醇对苯二氮卓敏感性的影响通过高迷宫行为来衡量。

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Rodents prenatally exposed to ethanol demonstrate altered behavioral and hormonal responses to stressful environments. Prenatal ethanol exposure may also have long-term effects on the offspring's GABAergic system. Using the elevated plus-maze, the present study examined the sensitivity of adult Sprague-Dawley rat offspring from prenatal ethanol (E), pair-fed (PF) and ad lib-fed control (C) conditions to the effects of benzodiazepine (BZD) on plus-maze behavior and corticosterone (CORT) responses. At 60-90 days of age, E, PF, and C males and females were injected subcutaneously with either BZD or saline. Twenty minutes later animals were placed in an open field (OF) for a 5-min test and then on the plus-maze for a 5 min test; behaviors were recorded during testing and blood samples collected at the end of testing for CORT determinations. Overall, sex differences were observed in both OF and plus-maze behaviors. Females showed more ambulation and rearing in the OF than males, and exhibited increased exploratory behaviors and decreased fear-related behaviors compared to males on the plus-maze. Following BZD treatment, both males and females exhibited increased time on open arms, increased open arm entries, and decreased time on closed arms compared to saline-treated males and females, regardless of prenatal treatment. These differences did not appear to be due to altered activity levels, as BZD treatment had no effect on total ambulation in the OF. Importantly, although no significant differences in plus-maze behaviors were found among saline-injected E, PF, and C males or females. BZD treatment differentially affected E males and females compared to their PF and C counterparts. Both E males and females treated with BZD spent increased time on open arms and decreased time on closed arms compared to their PF and C counterparts, suggesting decreased fear. Further, BZD-treated E males exhibited decreased open and closed arm entries, spent significantly more time in the central area, and had lower CORT levels, another index of fear or stress, compared to BZD-treated PF and C males. These data support and extend previous work demonstrating that the plus-maze provides a reliable measure of anxiety/fear, and that plus-maze behavior is sensitive to anxiolytic agents such as BZD. Furthermore, these data suggest that prenatal ethanol exposure may alter sensitivity to the effects of BZD on plus-maze behavior and CORT responsiveness, and may do so differentially in male and females offspring.
机译：产前暴露于乙醇的啮齿动物表现出对压力环境的行为和激素反应改变。产前乙醇暴露也可能对后代的GABA能系统产生长期影响。使用升高的迷宫，本研究检查了成年Sprague-Dawley大鼠后代在产前乙醇（E），成对喂养（PF）和自由喂养对照（C）条件下对苯二氮卓（BZD）的敏感性。 ）的迷宫行为和皮质酮（CORT）反应。在60-90天龄时，对E，PF和C的男性和女性进行皮下注射BZD或生理盐水。二十分钟后，将动物放置在开放场地（OF）中进行5分钟测试，然后放在迷宫中进行5分钟测试;在测试过程中记录行为，并在测试结束时收集血液样本以进行CORT测定。总体而言，在OF和迷宫行为中均观察到性别差异。与在迷宫中的男性相比，女性在男性中的走动和抚养比男性更多，并且表现出更多的探索行为和与恐惧相关的行为减少。在BZD治疗后，无论进行产前治疗如何，与生理盐水处理过的男性和女性相比，男性和女性在张开双臂上的时间都增加了，张开双臂进入的时间增加了，闭合手臂上的时间减少了。这些差异似乎不是由于活动水平的改变所致，因为BZD治疗对OF中的整体移动没有影响。重要的是，尽管在注射了生理盐水的E，PF和C雄性或雌性中，迷宫行为没有显着差异。与PF和C对应者相比，BZD治疗对E男女的影响不同。与PF和C相较，接受BZD治疗的E男性和女性在张开双臂上的时间都增加了，而在张开双臂上的时间减少了，这表明恐惧有所减轻。此外，与BZD治疗的PF和C雄性相比，BZD治疗的E雄性表现出减少的张开和闭合的手臂进入，在中部地区花费的时间明显更多，并且CORT水平较低，这是恐惧或压力的另一个指标。这些数据支持并扩展了以前的工作，证明了正迷宫可以可靠地衡量焦虑/恐惧，并且正迷宫的行为对诸如BZD等抗焦虑药敏感。此外，这些数据表明，产前乙醇暴露可能会改变对BZD对迷宫行为和CORT反应性的影响的敏感性，并且在雄性和雌性后代中可能有所不同。

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