• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Dopaminergic parameters during social isolation in low- and high-active mice.
【24h】

Dopaminergic parameters during social isolation in low- and high-active mice.

机译：低活动和高活动小鼠的社交隔离过程中的多巴胺能参数。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Alterations induced by social isolation (1 day to 18 weeks) in low- and high-active mice (LAM and HAM) were studied in respect to locomotor activity, [3H]-spiperone binding in the striatum, striatal, and cortical dopamine metabolism, and presynaptic dopaminergic sensitivity to apomorphine (0.75 mg/kg; i.p.). Isolated HAM and LAM showed increased locomotor activity compared to group-housed mice after long-term isolation (6-18 weeks). Considering the studied dopaminergic parameters, it has been found that social isolation did not affect striatal D2 receptors, striatal and cortical dopamine metabolism, and apomorphine-mediated reduction of dopaminergic metabolism. The change of housing conditions was generally associated with an increase of cortical dopamine metabolism after 1 week. Activity type specific differences in group-housed LAM and HAM were found in the basal striatal dopamine metabolism and in the sensitivity of the nigrostriatal system to autoreceptor activation. The reduced striatal dopamine metabolism and the higher presynaptic sensitivity of HAM may be related to their high active running wheel behavior.
机译：在运动能力，纹状体，纹状体和皮质多巴胺代谢中的[3H] -pipe烯酮结合方面，研究了低活动和高活动小鼠（LAM和HAM）中由社交隔离（1天至18周）引起的变化，以及对阿扑吗啡（0.75 mg / kg; ip）的突触前多巴胺能敏感性。长期隔离（6-18周）后，与分组饲养的小鼠相比，分离的HAM和LAM表现出运动能力增强。考虑到研究的多巴胺能参数，已经发现社会隔离并不会影响纹状体D2受体，纹状体和皮质多巴胺代谢以及阿扑吗啡介导的多巴胺能代谢减少。居住条件的改变通常与1周后皮质多巴胺代谢增加有关。小组饲养的LAM和HAM的活动类型特异性差异在基础纹状体多巴胺代谢和黑质纹状体系统对自身受体激活的敏感性中发现。 HAM的纹状体多巴胺代谢降低和突触前敏感性较高可能与它们的高主动滚轮行为有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号