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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Acutely administered clozapine does not modify naloxone-induced withdrawal jumping in morphine-dependent mice.
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Acutely administered clozapine does not modify naloxone-induced withdrawal jumping in morphine-dependent mice.

机译：急性服用氯氮平不会改变吗啡依赖性小鼠中纳洛酮引起的戒断反应。

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摘要

A direct comparison of the effects of clozapine and haloperidol upon naloxone-induced withdrawal jumping was investigated in morphine-dependent mice, as this syndrome may provide a behavioral baseline to differentiate between the two neuroleptics. Neither clozapine ((0.03-3.0 mg/kg s.c., n=9-10) nor haloperidol (0.01-04).1 mg/kg s.c., n=9-10) affected withdrawal jumping precipitated by 0.1 or 15.0 mg/kg i.p. naloxone in morphine-dependent mice. Measurement of locomotor activity immediately prior to naloxone administration revealed a dose-dependent reduction in activity by both compounds, indicating pharmacological effects at the time of naloxone-induced withdrawal. Clonidine (0.02-0.5 mg/kg s.c., n=9-10) also had no affect upon withdrawal jumping, although reductions in locomotor activity prior to naloxone administration were detected. There is no difference in the effects of acutely administered clozapine and haloperidol upon naloxone-precipitated withdrawal jumping in morphine-dependent mice.
机译：在吗啡依赖性小鼠中研究了氯氮平和氟哌啶醇对纳洛酮诱导的戒断跳动的影响的直接比较，因为该综合征可能提供区分两种抗精神病药的行为基线。氯氮平（（0.03-3.0 mg / kg s.c.，n = 9-10）和氟哌啶醇（0.01-04）.1 mg / kg s.c.，n = 9-10）均未影响以0.1或15.0 mg / kg i.p.沉淀的停跳跳跃。吗啡依赖性小鼠的纳洛酮。在纳洛酮给药之前立即测量运动活性，发现这两种化合物的活性呈剂量依赖性降低，表明纳洛酮诱发戒断时的药理作用。可乐定（0.02-0.5 mg / kg s.c.，n = 9-10）对停跳也没有影响，尽管在纳洛酮给药前运动能力降低了。在吗啡依赖性小鼠中，急性给予的氯氮平和氟哌啶醇对纳洛酮沉淀的戒断跳动的影响没有差异。

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