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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effect of ethanol on extracellular dopamine in the nucleus accumbens of alcohol-preferring AA and alcohol-avoiding ANA rats.
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Effect of ethanol on extracellular dopamine in the nucleus accumbens of alcohol-preferring AA and alcohol-avoiding ANA rats.

机译：乙醇对优选酒精的AA和避免酒精的ANA大鼠伏隔核中细胞外多巴胺的影响。

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摘要

The role of central monoamines in the genetically determined influences on voluntary ethanol consumption were examined by studying the extracellular levels of monoamines in the nucleus accumbens of the alcohol-preferring AA (Alko Alcohol) and alcohol-avoiding ANA (Alko Nonalcohol) rats with in vivo microdialysis. Dialysate samples for the assay of monoamines with small bore HPLC were collected from freely moving animals at 15 min intervals after administration of ethanol (0.5, 1, or 2 g/kg, i.p.). Ethanol significantly increased the extracellular levels of dopamine, DOPAC, and HVA, suggesting stimulation of dopamine release by ethanol, while the effect on 5-HIAA did not reach significance. No difference in the extent or time course of stimulation of dopamine release between the AA and ANA rats was found. The results could so far give no indication that the differential ethanol consumption by AA and ANA rats could be explained in terms of differences in ethanol-induced stimulation of dopamine release inthe nucleus accumbens.
机译：通过研究体内偏好乙醇的AA（Alko Alcohol）和避免酒精的ANA（Alko Nonalcohol）大鼠伏隔核中单胺的细胞外水平，研究了中央单胺在遗传决定的对自愿性乙醇摄入的影响中的作用。微透析。在施用乙醇（0.5、1或2 g / kg，腹腔注射）后，以15分钟的间隔从自由活动的动物中收集用于单胺分析的透析液样品。乙醇显着增加了细胞外多巴胺，DOPAC和HVA的水平，表明乙醇刺激了多巴胺的释放，而对5-HIAA的影响并未达到显着水平。在AA和ANA大鼠之间，在刺激多巴胺释放的程度或时间过程上没有差异。到目前为止，结果尚无迹象表明，AA和ANA大鼠的乙醇消耗差异可以用乙醇诱导伏伏核中多巴胺释放的刺激差异来解释。

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