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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Cortical ablation and drug-induced changes in striatal ascorbic acid oxidation and behavior in the rat.
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Cortical ablation and drug-induced changes in striatal ascorbic acid oxidation and behavior in the rat.

机译：皮质消融和药物诱导的大鼠纹状体抗坏血酸氧化和行为变化。

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Rats whose frontoparietal cortex had been bilaterally ablated were allowed 21 days for recovery and then treated with apomorphine (APO), 1 mg/kg SC or scopolamine (SCOP), 0.6 mg/kg SC. Soon after a behavioral test, dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), ascorbic acid (AA), and dehydroascorbic acid (DHAA) levels were determined by HPLC/EC in striatal synaptosomes (left side) and whole striatum (right side). SCOP behavioural effects were attenuated by cortical ablation, while those of APO were affected to a lesser extent. In the striatum of unoperated and sham-operated rats DHAA contents and DHAA/AA ratio resulted increased after drugs administration. No change in AA oxidation was observed in the striatum of ablated rats. In the synaptosomes of unoperated and sham-operated rats both drugs led to a decrease in DHAA contents and DHAA/AA ratio. In unoperated and sham-operated rats APO and SCOP caused a decrease of the DOPAC/DA ratio in the whole striatum and striatal synaptosomes. In ablatedrats APO caused a decrease of DOPAC/DA ratio in the whole striatum and synaptosomes, while SCOP effects on DA turnover resulted attenuated in the whole striatum and abolished in synaptosomes. We conclude that drug-induced AA oxidation is likely to occur in the extracellular space and requires intact corticostriatal glutamatergic pathways. The latter may play an enabling role in SCOP behavioral effects.
机译：将双侧额叶前额皮质切除的大鼠恢复21天，然后用1mg / kg SC的阿扑吗啡（APO）或0.6mg / kg SC的东pol碱（SCOP）处理。进行行为测试后不久，通过HPLC / EC测定了纹状体突触小体（左侧）和整个纹状体中的多巴胺（DA），3,4-二羟基苯基乙酸（DOPAC），抗坏血酸（AA）和脱氢抗坏血酸（DHAA）的水平。 （右边）。皮层消融减弱了SCOP行为的影响，而APO的影响较小。在未手术和假手术大鼠的纹状体中，给药后，DHAA含量和DHAA / AA比增加。在消融大鼠的纹状体中未观察到AA氧化的变化。在未手术和假手术大鼠的突触小体中，两种药物均导致DHAA含量和DHAA / AA比降低。在未经手术和假手术的大鼠中，APO和SCOP导致整个纹状体和纹状体突触小体中的DOPAC / DA比降低。在消融的大鼠中，APO导致整个纹状体和突触小体中的DOPAC / DA比降低，而SCOP对DA转换的影响导致整个纹状体减弱，并在突触小体中消失。我们得出的结论是，药物诱导的AA氧化很可能发生在细胞外空间，并且需要完整的皮质激素谷氨酸能途径。后者可能在SCOP行为影响中起促进作用。

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