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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of drug discrimination history on anti-punishment properties of chlordiazepoxide in rats.
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Effects of drug discrimination history on anti-punishment properties of chlordiazepoxide in rats.

机译：药物歧视史对大鼠氯二氮卓抗惩罚特性的影响。

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摘要

Several studies have indicated that acquiring discriminative stimulus control for a certain anxiolytic drug influences its subsequent anti-conflict properties. To further elaborate on the question whether drug discrimination procedures affect behaviour in a conflict paradigm, a classical two-lever drug discrimination procedure was combined with an operant conflict procedure within the same animals. To this extent, rats were trained to discriminate the anxiolytic chlordiazepoxide (CDP, 30 mg/kg, po) from saline (SAL), and subsequently punished responding periods were introduced within the same session. In addition to the rats that were trained to discriminate CDP from vehicle, a group of rats was trained on a random relationship between CDP and the rewarded lever. CDP and alprazolam completely substituted for CDP, whereas mianserin did not. Responding during punished components in a session was increased by CDP and alprazolam, but not by mianserin in rats that were trained to discriminate CDP from vehicle and in randomly trained rats. The data indicate that rats can be reliably trained and tested in drug discrimination and conflict procedures within a single session and that CDP's discriminative stimulus does not alter its anti-conflict effects.
机译：几项研究表明，获得对某种抗焦虑药的歧视性刺激控制会影响其随后的抗冲突特性。为了进一步阐述毒品歧视程序是否会影响冲突范式中的行为的问题，将经典的两杆毒品歧视程序与同一动物内的操作性冲突程序相结合。在此程度上，训练大鼠区分盐水（SAL）中的抗焦虑药氯二氮卓（CDP，30 mg / kg，po），随后在同一疗程中引入惩罚期。除了训练了将CDP与媒介物区分开的大鼠外，还对一组大鼠进行了CDP和奖励杠杆之间随机关系的训练。 CDP和阿普唑仑完全替代了CDP，而棉桃素却没有。在训练中区分CDP与媒介物的大鼠和随机训练的大鼠中，CDP和阿普唑仑增加了在一个环节中受罚成分期间的反应，但米安色林却没有。数据表明，可以在一个疗程内对大鼠进行药物歧视和冲突程序的可靠培训和测试，并且CDP的歧视性刺激不会改变其抗冲突作用。

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