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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Role of D(1) and D(2) dopamine receptors in the acquisition and expression of flavor-preference conditioning in sham-feeding rats.
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Role of D(1) and D(2) dopamine receptors in the acquisition and expression of flavor-preference conditioning in sham-feeding rats.

机译：D（1）和D（2）多巴胺受体在以假喂养的大鼠中获取和表达风味偏好条件的作用。

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摘要

The present study examined the effects of D(1) and D(2) antagonists on flavor-preference conditioning by the sweet taste of sucrose. All sessions were conducted under sham-feeding conditions to minimize post-ingestive influences. The rats were trained in alternating, one-bottle sessions to sham-feed a 16% sucrose solution containing one novel flavor (CS+) and a less-preferred 0.2% saccharin solution containing a different flavor (CS-). Three groups of food-restricted rats were treated with either vehicle (control group), the D(1) antagonist, SCH23390 (200 nmol/kg), or the D(2) antagonist, raclopride (200 nmol/kg) during one-bottle training. A fourth group (yoked group) was vehicle-treated and its training intakes were matched to that of the D(1) and D(2) drug groups. Preferences were assessed in two-bottle tests with the CS+ and CS- flavors presented in mixed 8% sucrose+0.1% saccharin solutions following systemic doses of 0, 200, or 800 nmol/kg of either the D(1) or D(2) antagonists. All groups significantly preferred the CS+ flavor in vehicle tests, although the preferences were weaker in the D(1), D(2), and yoked groups compared to the control group. All groups selectively reduced their CS+ intakes when treated with either D(1) or D(2) antagonists during two-bottle testing, and the CS+ preference was blocked at the higher doses. These data show that D(1) and D(2) receptor antagonists block the expression of a sucrose-conditioned preference, but produces substantially lesser effects upon the acquisition of this form of flavor conditioning.
机译：本研究通过蔗糖的甜味检验了D（1）和D（2）拮抗剂对风味偏好条件的影响。所有会议均在假饲喂条件下进行，以最大程度地减少食后感。在交替的一瓶训练中对大鼠进行训练，以假喂养含有一种新香料（CS +）的16％蔗糖溶液和含有另一种香料（CS-）的次佳0.2％糖精溶液。三组食物受限的大鼠在接受下列药物治疗的过程中，分别用媒介物（对照组），D（1）拮抗剂SCH23390（200 nmol / kg）或D（2）拮抗剂雷洛必利（200 nmol / kg）治疗。瓶子训练。第四组（带轭组）接受了媒介治疗，其训练摄入量与D（1）和D（2）药物组的摄入量相匹配。在两瓶测试中对CS +和CS-风味剂在8％蔗糖+ 0.1％糖精溶液中呈递后的全身性剂量分别为0、200或800 nmol / kg D（1）或D（2）进行评估）拮抗剂。尽管与对照组相比，D（1），D（2）和带轭组的偏好较弱，但所有组在媒介物测试中均显着偏爱CS +风味。当在两瓶试验中用D（1）或D（2）拮抗剂治疗时，所有组均选择性降低CS +摄入量，并且在较高剂量下CS +偏爱被阻断。这些数据表明，D（1）和D（2）受体拮抗剂可阻止蔗糖条件化偏好表达的表达，但在获得这种形式的风味条件调解后，其产生的影响要小得多。

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