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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Temporal analysis of the rat's behavior in the plus-maze: effect of midazolam.
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Temporal analysis of the rat's behavior in the plus-maze: effect of midazolam.

机译：时空分析大鼠在迷宫中的行为：咪达唑仑的作用。

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摘要

The aim of the present study was to carry out a temporal analysis of the midazolam (MDZ)-induced anxiolysis in rats submitted to the elevated plus-maze (EPM) test. Male Wistar rats received either MDZ (0.5, 1.0 and 1.5 mg.kg(-1)) or saline (0.9%) and were submitted to the EPM test. Temporal analysis revealed that the group receiving MDZ (1.5 mg.kg(-1)), as well as the group treated with saline, displayed low %Open arm entries, which suggests increased anxiety over the test period. Motor activity, evaluated by the enclosed arm entries, was also decreased in both experimental groups, thus suggesting locomotor habituation. The treatment with MDZ (1.5 mg. kg(-1)) induced a clear anxiolysis during the first 3 min, but not at the end of the test, since only the %Open arm time remained increased. The data are discussed with reference to the lack of the test's sensitivity to alterations in the level of anxiety over time and with respect to a qualitative shift in the experimental anxiety at the end of the session.
机译：本研究的目的是对咪达唑仑（MDZ）引起的高迷宫（EPM）测试大鼠的抗焦虑作用进行时间分析。雄性Wistar大鼠接受MDZ（0.5、1.0和1.5 mg.kg（-1））或生理盐水（0.9％），并接受EPM测试。时间分析显示，接受MDZ（1.5 mg.kg（-1））的组以及接受生理盐水处理的组显示出较低的开臂率，这表明在测试期间焦虑加剧。在两个实验组中，通过封闭的手臂进入评估的运动活动也降低了，因此表明运动习惯。用MDZ（1.5 mg。kg（-1））进行的治疗在前3分钟内引起明显的抗焦虑作用，但在试验结束时未引起明显的抗焦虑作用，因为仅增加了％Open arm时间。讨论数据时参考了测试对焦虑水平随时间变化的敏感性的缺乏以及在会议结束时实验性焦虑的质变。

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