• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Time-dependent alterations in ICSS thresholds associated with repeated amphetamine administrations.
【24h】

Time-dependent alterations in ICSS thresholds associated with repeated amphetamine administrations.

机译：ICSS阈值的时间依赖性变化与重复的苯丙胺给药有关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The time interval between successive injections of psychostimulant drugs, such as amphetamine, plays an important role in the development of neuroadaptive responses to these drugs. Changes in reward function were quantified using a discrete-trial current-intensity paradigm to determine thresholds for lateral hypothalamic electrical self-stimulation after experimenter-administered amphetamine injections (4 mg/kg, IP) at 1- and 5-day intervals. Repeated administration of amphetamine produced progressive changes in ICSS behavior that were dependent on the time interval between injections. The acute effects of amphetamine on ICSS thresholds were potentiated, and threshold elevations associated with withdrawal from the drug diminished after repeated drug challenges at 5-day intervals. By contrast, daily injections of the same dose of amphetamine did not alter the acute threshold-lowering effect of the drug, but resulted in progressive increments in thresholds at later time points. Notably, the decreases in response latency produce by acute amphetamine administration were potentiated by both exposure regimens, which indicates a dissociation of drug effects on motor performance and brain stimulation reward. Thus, the distinct components of changes in reward function associated with acute amphetamine administration and subsequent withdrawal were differentially altered by the two exposure regimens, suggesting that the pattern of exposure is an important determinant of neuroadaptive responses to the drug.
机译：连续注射精神刺激药（例如苯丙胺）之间的时间间隔在对这些药物的神经适应性反应的发展中起重要作用。使用离散试验电流强度范式对奖励功能的变化进行量化，以确定在实验者每隔1天和5天注射一次苯丙胺（4 mg / kg，IP）后下丘脑外侧自我刺激的阈值。重复给予苯丙胺会导致ICSS行为的进行性改变，这取决于注射之间的时间间隔。苯丙胺对ICSS阈值的急性作用得到了加强，并且每隔5天重复用药一次后，与退出药物有关的阈值升高就降低了。相比之下，每天注射相同剂量的苯丙胺并不会改变药物的急性降低阈值的作用，但是会导致在随后的时间点阈值的逐步增加。值得注意的是，两种暴露方案均能加强急性苯丙胺给药所引起的反应潜伏期的减少，这表明药物对运动表现和脑刺激奖励的作用已消失。因此，与急性苯丙胺给药和随后的撤药有关的奖励功能变化的不同组成部分，通过两种暴露方案有差异地改变，这表明暴露方式是对该药物神经适应性反应的重要决定因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号