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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Differences in anxiety-related behavior and response to diazepam in BALB/cByJ and C57BL/6J strains of mice.
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Differences in anxiety-related behavior and response to diazepam in BALB/cByJ and C57BL/6J strains of mice.

机译：小鼠BALB / cByJ和C57BL / 6J品系的焦虑相关行为和对地西epa的反应差异。

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摘要

The study in an ethological perspective of inbred strains of mice offers a more accurate description of anxiety-related behavior. In this context, behavioral performances of the BALB/cByJ and C57BL/6J strains were systematically compared in the staircase test, the light/dark test and the elevated plus maze test. A rarely used variable, the latency of the first entry in the dark box, was also recorded in the light/dark test. A new statistical approach to this measure meant that specific avoidance strategies could be differentiated in the two strains. A study of the behavioral responses of the two strains given treatment with diazepam, a widely used anxiolytic compound, was also carried out. Results showed substantial differences between BALB/cByJ and C57BL/6J strains. C57BL/6J mice had high baseline activity and exploration of a new environment, suggesting a low level of anxiety. BALB/cByJ mice displayed defensive and protective behavior, with limited exploration of the new environment together with low locomotor activity. The response to diazepam was also different for each strain: C57BL/6J mice showed higher sensitivity to diazepam treatment than did BALB/cByJ mice.
机译：从小鼠近交系的伦理学角度进行的研究提供了与焦虑相关行为的更准确描述。在这种情况下，在阶梯测试，明/暗测试和高架迷宫测试中系统地比较了BALB / cByJ和C57BL / 6J菌株的行为表现。在明暗测试中也记录了一个很少使用的变量，即暗框中第一个条目的等待时间。一种针对该措施的新统计方法意味着可以在两种菌株中区分特定的回避策略。还研究了用地西epa（一种广泛使用的抗焦虑化合物）治疗的两种菌株的行为反应。结果显示BALB / cByJ和C57BL / 6J菌株之间存在实质性差异。 C57BL / 6J小鼠具有较高的基线活性和对新环境的探索，表明其焦虑水平较低。 BALB / cByJ小鼠表现出防御和保护行为，对新环境的探索有限，运动能力低。每个品系对地西epa的反应也不同：C57BL / 6J小鼠对地西epa治疗的敏感性高于BALB / cByJ小鼠。

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