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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Acute effects of d-amphetamine during the early and late follicular phases of the menstrual cycle in women.
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Acute effects of d-amphetamine during the early and late follicular phases of the menstrual cycle in women.

机译：d-苯异丙胺在女性月经周期的早期和晚期卵泡期的急性作用。

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Recent preclinical evidence indicates that ovarian hormones, such as estrogen and progesterone, may influence the behavioral effects of psychoactive drugs by interacting directly with neurotransmitter systems in the central nervous system. However, few studies have examined the effects of ovarian hormones on subjective or behavioral responses to psychoactive drugs in humans. In the present study, we assessed the subjective and physiological effects of d-amphetamine during the early and late follicular phases of the menstrual cycle. Nineteen healthy, regularly-cycling women participated in four sessions receiving doses of d-amphetamine (AMPH; 15 mg oral) or placebo during the early and late follicular phases of two menstrual cycles. During the early follicular phase levels of both estrogen and progesterone are low, whereas during the late follicular phase estrogen levels are higher while progesterone remains low. Dependent measures included self-report questionnaires, physiological measures and plasma hormone levels. Most of the subjective and physiological effects of AMPH were not affected by menstrual cycle phase. However, subjects reported greater Unpleasant Stimulation after AMPH, and less Unpleasant Sedation, during the late follicular phase than during the early follicular phase. These results provide limited evidence that higher levels of estrogen during the late follicular phase alter the subjective effects of AMPH in normal, healthy women.
机译：最近的临床前证据表明，卵巢激素，例如雌激素和孕激素，可能通过与中枢神经系统中的神经递质系统直接相互作用而影响精神活性药物的行为效果。但是，很少有研究检查卵巢激素对人类对精神药物的主观或行为反应的影响。在本研究中，我们评估了d-苯异丙胺在月经周期的早期和晚期卵泡期的主观和生理学作用。在两个月经周期的早期和晚期卵泡期，有19名健康，定期骑自行车的妇女参加了四个疗程，接受了d-苯异丙胺（AMPH; 15 mg口服）或安慰剂。在卵泡早期，雌激素和孕激素水平都较低，而在卵泡晚期，雌激素水平较高，而孕激素仍然较低。相关措施包括自我报告调查表，生理措施和血浆激素水平。 AMPH的大多数主观和生理作用不受月经周期期的影响。然而，与卵泡早期相比，在卵泡晚期，受试者在AMPH后的刺激性更大，而镇静作用则更少。这些结果提供了有限的证据，表明在卵泡晚期，较高水平的雌激素会改变AMPH对正常健康女性的主观影响。

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