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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Progesterone treatment during the early follicular phase of the menstrual cycle: effects on smoking behavior in women.
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Progesterone treatment during the early follicular phase of the menstrual cycle: effects on smoking behavior in women.

机译：月经周期早期卵泡期的孕酮治疗：对女性吸烟行为的影响。

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摘要

The goals of this study were (1) to examine the feasibility of administering progesterone to women during the early follicular phase when the endogenous estradiol and progesterone levels are low, and (2) to investigate the effects of oral progesterone treatment on smoking behavior in female smokers. Twelve subjects had two experimental sessions, within 3-9 days after the beginning of their menses. In each experimental session, subjects received a single 200-mg dose of progesterone or placebo, orally. Two and a half hours after the medication treatment, subjects were assessed for subjective response to two puffs of a cigarette and then started the self-administration period in which they had the option to exchange their token for two puffs of cigarette, 15 min apart. Subjects had low levels of estradiol and progesterone before the first and second sessions. Plasma progesterone levels peaked in 2 h following progesterone treatment. Progesterone treatment attenuated the craving for and subjective effects from smoking. Under progesterone treatment, there was a trend for decreased smoking behavior. These preliminary results suggest that the early follicular phase of the menstrual cycle may be a useful interval to investigate the effects of exogenous progesterone in female smokers. The effects of progesterone on nicotine dependence need to be studied further.
机译：这项研究的目的是（1）研究内源性雌二醇和孕酮水平低时在卵泡早期向妇女服用孕酮的可行性，以及（2）研究口服孕酮治疗对女性吸烟行为的影响吸烟者。在月经开始后的3到9天内，十二名受试者进行了两次实验。在每个实验阶段，受试者口服口服200 mg孕激素或安慰剂。药物治疗后两个半小时，评估受试者对两根香烟的主观反应，然后开始自我管理，在此期间，他们可以选择将自己的代币换成两根香烟，间隔15分钟。在第一节和第二节之前，受试者的雌二醇和孕酮水平较低。孕酮治疗后2小时血浆孕酮水平达到峰值。孕酮治疗可减轻吸烟的渴望和主观影响。在孕激素治疗下，吸烟行为有减少的趋势。这些初步结果表明，月经周期的早期卵泡期可能是研究外源性孕酮对女性吸烟者影响的有用间隔。孕酮对尼古丁依赖性的影响需要进一步研究。

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