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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Chronic nicotine administration in the drinking water affects the striatal dopamine in mice.
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Chronic nicotine administration in the drinking water affects the striatal dopamine in mice.

机译：饮用水中的慢性尼古丁给药会影响小鼠的纹状体多巴胺。

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摘要

Although tobacco contains a large variety of substances, its addictive properties are most probably due to the reinforcing actions of nicotine that motivates continued tobacco use. Animals and humans self-administer nicotine, a response that appears to involve the mesolimbic dopamine system and to be common to other abused drugs. The present article reviews animal models to administer nicotine chronically. We also describe a new animal model in which nicotine is given to mice in drinking water as their sole source of fluid. This treatment produced nicotine plasma concentrations comparable to or above those found in smokers. We found that mice withdrawn from nicotine were tolerant to the effects of nicotine challenge on striatal dopamine metabolism as well as on body temperature and locomotor activity. Furthermore, 3H-nicotine binding in the cortex and midbrain was significantly increased in mice withdrawn from nicotine. The last part of the article will focus on the effects of this chronic nicotine treatment on striatal dopamine. Dopamine and its metabolites and locomotor activity were increased in the forenoon in mice still drinking nicotine solutions. We also report recent data in which chronic nicotine administration in the drinking water enhanced the effect of dopamine receptor agonist, quinpirole, on striatal metabolism. The animal model described appears to be a relevant method for studying the mechanisms that are thought to be involved in nicotine dependence.
机译：尽管烟草包含多种物质，但其成瘾性很可能是由于尼古丁的增强作用激发了持续使用烟草。动物和人类自我管理尼古丁，这种反应似乎涉及中脑边缘多巴胺系统，并且在其他滥用药物中很常见。本文概述了动物模型，以长期施用尼古丁。我们还描述了一种新的动物模型，其中将尼古丁作为饮用水的唯一来源提供给小鼠饮用水。这种治疗产生的尼古丁血浆浓度与吸烟者的血浆浓度相当或更高。我们发现从尼古丁中撤出的小鼠可耐受尼古丁激发对纹状体多巴胺代谢以及体温和运动功能的影响。此外，从烟碱中撤出的小鼠中，皮质和中脑中的3H烟碱结合显着增加。本文的最后一部分将重点讨论这种慢性尼古丁治疗对纹状体多巴胺的影响。多巴胺及其代谢物和运动活性在前额仍在喝尼古丁溶液的小鼠中增加。我们还报告了最近的数据，其中在饮用水中长期服用尼古丁可增强多巴胺受体激动剂喹吡罗对纹状体代谢的影响。所描述的动物模型似乎是研究被认为与尼古丁依赖性有关的机制的一种相关方法。

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