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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Differences in drug-induced place conditioning between BALB/c and C57Bl/6 mice.
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Differences in drug-induced place conditioning between BALB/c and C57Bl/6 mice.

机译：BALB / c和C57Bl / 6小鼠在药物诱导的位置调节上的差异。

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摘要

The influence of genotype on the rewarding effects of morphine (0, 1, 3, and 9 mg/kg), amphetamine (0, 0.5, 1, and 2 mg/kg), and cocaine (0, 2.5, 5, and 10 mg/kg) was examined in a place-conditioning paradigm. Two strains of mice, the BALB/cByJIco and the C57BL/6JIco, were used, notably because of their high difference in novelty-seeking behavior. Indeed, high novelty seeking has been associated with an increased risk for using drugs of abuse. Results clearly show that C57BL/6 mice display a conditioned place preference for stimuli paired with morphine, amphetamine, or cocaine. In contrast, BALB/c mice demonstrated place preference to morphine and place aversion to amphetamine, while cocaine was ineffective at the doses tested. No treatment induced differences in the locomotion measured in a drug-free condition. Results may be related to differences at the behavioral (difference in novelty seeking) or neurochemical level (differences in catecholaminergic or opioidergic neurotransmission).
机译：基因型对吗啡（0、1、3和9 m​​g / kg），苯丙胺（0、0.5、1和2 mg / kg）和可卡因（0、2.5、5和10）的奖励作用的影响mg / kg）在场所条件范式中进行检查。使用了两种小鼠品系BALB / cByJIco和C57BL / 6JIco，这是因为它们在寻求新奇行为方面有很大差异。确实，寻求新颖性与使用滥用药物的风险增加有关。结果清楚地表明，C57BL / 6小鼠对与吗啡，苯丙胺或可卡因配对的刺激物表现出条件性的位置偏爱。相反，BALB / c小鼠表现出对吗啡的偏爱和对苯丙胺的厌恶，而可卡因在测试剂量下无效。在无药物条件下，没有治疗可引起运动差异。结果可能与行为（寻求新奇的差异）或神经化学水平（儿茶酚胺能或视皮醇能神经传递的差异）的差异有关。

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