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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Behaviour of pigs given corticotrophin-releasing hormone in combination with flumazenil or diazepam.
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Behaviour of pigs given corticotrophin-releasing hormone in combination with flumazenil or diazepam.

机译：给予促肾上腺皮质激素释放激素与氟马西尼或地西epa合用的猪的行为。

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摘要

The possible involvement of an endogenous benzodiazepine (BZ) inverse agonist in the activational effects of corticotrophin-releasing hormone (CRH) on behaviour was examined in pigs given porcine CRH (75 microg) intracerebroventricularly (i.c.v.) and the BZ antagonist flumazenil (FLU; 0.09 mg/kg) intravenously (i.v.). In Experiment 1, behaviour was recorded for 75 min in pigs (n=5) given i.v. FLU or saline (SAL) followed by i.c.v. CRH or vehicle (VEH). Significant changes in arousal, posture and oro-nasal activity were induced by CRH, whereas FLU alone had no effect but appeared to reduce some responses to CRH. In Experiment 2, behaviour was observed for 60 min in pigs (n=6) given i.c.v. CRH followed by i.v. FLU, VEH or diazepam (DZ; 0.2 mg/kg). Behavioural responses to CRH, however, were unaffected by FLU, whereas certain aspects of arousal, posture and oro-nasal activity were reduced by DZ; a higher dose of DZ (0.3 mg/kg) given before CRH tended to enhance these inhibitory effects. All treatments also produced similar increases in plasma cortisol. Taken together with previous findings, the negligible effect of FLU in this study suggests that endogenous ligands for the BZ binding site on the GABA(A) receptor are of little importance in regulating the behavioural actions of CRH in swine.
机译：在给予猪CRH（75微克）脑室内（icv）和BZ拮抗剂氟马西尼（FLU; 0.09）的猪中，检查了内源性苯二氮杂（BZ）反向激动剂可能参与促肾上腺皮质激素释放激素（CRH）对行为的激活作用。静脉注射（iv）。在实验1中，记录了i.v.的猪（n = 5）行为75分钟。 FLU或生理盐水（SAL），然后进行静脉内CRH或车辆（VEH）。 CRH引起唤醒，姿势和口鼻活动的显着变化，而仅FLU无效，但似乎减少了对CRH的某些反应。在实验2中，在i.c.v.的条件下，观察了60分钟的行为（n = 6）。 CRH，然后是i.v. FLU，VEH或地西epa（DZ; 0.2 mg / kg）。但是，对CRH的行为反应不受FLU的影响，而DZ减少了某些唤醒，姿势和口鼻活动的方面;在CRH之前给予较高剂量的DZ（0.3 mg / kg）倾向于增强这些抑制作用。所有治疗也使血浆皮质醇产生相似的增加。结合以前的发现，在本研究中FLU的影响可忽略不计，这表明GABA（A）受体上BZ结合位点的内源性配体在调节猪CRH的行为方面并不重要。

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