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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The NMDA antagonist EAA 494 does not impair working memory in an operant DNMTP task in rats.
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The NMDA antagonist EAA 494 does not impair working memory in an operant DNMTP task in rats.

机译：NMDA拮抗剂EAA 494不会损害大鼠进行DNMTP时的工作记忆。

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摘要

There is contrasting evidence for an impairment of spatial working memory in operant delayed matching/or nonmatching to position (DMTP/DNMTP) tasks, as both delay-dependent and -independent disruption of choice accuracy has been found following N-methyl-D-aspartate (NMDA) receptor blockade. Using a within-subjects experimental design, the effect of the competitive NMDA receptor antagonist, EAA 494 (D-CPP-ene) (1, 1.5, 2 mg/kg IP 30 min prior), on working memory was investigated in male Lister Hooded rats pretrained to the DNMTP task (0-16-s delay in intervals). Metal barriers were inserted between the food magazine and levers to inhibit the use of mediating strategies, such as orientation towards the correct lever during the delay interval, because this behavior may contribute to the delay-dependent disruption noted in previous studies. It was found that EAA 494 did not modify working memory either in the presence or absence of barriers. However, a dose-dependent impairment of task performance was recorded, notably in the presence of barriers. These results indicate that competitive blockade of NMDA receptors with EAA 494 does not result in impaired working memory in rats and parallel the lack of effect of the compound upon working memory in humans. Activation of NMDA receptors does not appear to be essential for the performance of spatial tasks requiring working memory.
机译：有相反的证据表明，在操作性延迟匹配/或位置不匹配（DMTP / DNMTP）任务中，空间工作记忆受到损害，因为在N-甲基-D-天冬氨酸后发现了延迟依赖性和非依赖性选择准确性的破坏。 （NMDA）受体阻滞。使用受试者内部实验设计，研究了竞争性NMDA受体拮抗剂EAA 494（D-CPP-ene）（在30分钟之前分别以1、1.5、2 mg / kg IP注射）对男性Lister Hooded的工作记忆的影响接受DNMTP任务预训练的大鼠（间隔时间为0-16-s）。在食品盒和杠杆之间插入了金属屏障，以禁止使用调解策略，例如在延迟间隔内朝向正确的杠杆定向，因为这种行为可能会导致先前研究中指出的与延迟相关的破坏。发现在存在或不存在障碍的情况下，EAA 494都不会改变工作记忆。但是，记录了任务执行的剂量依赖性损害，特别是在存在障碍的情况下。这些结果表明，用EAA 494竞争性阻断NMDA受体不会导致大鼠的工作记忆受损，并且与该化合物对人的工作记忆缺乏作用无关。 NMDA受体的激活对于执行需要工作记忆的空间任务似乎并不是必不可少的。

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