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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of beta-phenylethylamine on the hypothalamo-pituitary-adrenal axis in the male rat.
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Effects of beta-phenylethylamine on the hypothalamo-pituitary-adrenal axis in the male rat.

机译：β-苯乙胺对雄性大鼠下丘脑-垂体-肾上腺轴的影响。

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摘要

beta-Phenylethylamine (PEA) is a trace neuroactive amine implicated in the regulation of the hypothalamic-pituitary-adrenal (HPA) response to stress. To test this hypothesis, effects of subchronic levels of PEA (50 mg/kg/day treatment for 10 days) on the corticotroph function were studied. PEA treatment induces: (i) a significant increase of corticotrophin releasing hormone (CRH) immunoreactivity in the median eminence (ME), as measured by semi-quantitative immunofluorescence labeling techniques, (ii) a significant increase in CRH mRNA levels in paraventricular nuclei, as detected by in situ hybridization, and (iii) an increase in plasma adreno-corticotrophin hormone (ACTH) and corticosterone levels in responses to stress. PEA treatment has no effect on the number of binding sites and on the dissociation constant of the glucocorticoid receptors in any structure studied. Results of the dexamethasone suppression test were similar in PEA- and saline-treated rats. Taken together, these results suggest that PEA treatment stimulated the HPA axis activity levels directly via the CRH hypothalamic neurons, without altering the negative feed back control exerted by the glucocorticoids.
机译：β-苯乙胺（PEA）是一种微量神经活性胺，涉及调节对压力的下丘脑-垂体-肾上腺（HPA）反应。为了验证这一假设，研究了亚慢性水平的PEA（50 mg / kg /天的治疗10天）对皮质营养功能的影响。通过半定量免疫荧光标记技术测量，PEA治疗可诱导：（i）中位隆起（ME）中促肾上腺皮质激素释放激素（CRH）免疫反应的显着增加;（ii）室旁核中CRH mRNA水平的显着增加，如通过原位杂交所检测到的;以及（iii）响应应激而使血浆肾上腺皮质激素（ACTH）和皮质酮水平升高。 PEA处理对所研究的任何结构中的结合位点数目和糖皮质激素受体的解离常数均无影响。地塞米松抑制试验的结果在PEA和盐水处理的大鼠中相似。综上所述，这些结果表明，PEA处理直接通过CRH下丘脑神经元刺激了HPA轴活性水平，而没有改变糖皮质激素的负反馈控制。

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