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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Opioid receptor involvement in the adaptation to motion sickness in Suncus murinus.
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Opioid receptor involvement in the adaptation to motion sickness in Suncus murinus.

机译：阿片受体参与了对日光浴动晕病的适应。

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The aim of the present study was to investigate an opioid receptor involvement in the adaptation response to motion sickness in Suncus murinus. Different groups of animals were treated intraperitoneally with either saline, morphine (0.1 and 1.0 mg/kg), naloxone (1.0, 10.0 and 5.0 mg/kg) or a combination of naloxone plus morphine in the absence or 30 min prior to a horizontal motion stimulus of 1 Hz and 40 mm amplitude. For the study of adaptation, different groups received saline on the first trial, and in subsequent trials (every 2 days) they received either saline, naloxone (1.0 and 10.0 mg/kg, i.p.) or morphine (0.1 mg/kg, i.p.) 30 min prior to the motion stimulus. Pretreatment with morphine caused a dose-related reduction in emesis induced by a single challenge to a motion stimulus. Pretreatment with naloxone alone did not induce emesis in its own right nor did it modify emesis induced by a single challenge to a motion stimulus. However, pretreatment with naloxone (5.0 mg/kg, i.p.) revealed an emetic response to morphine (P<.001) (1.0 mg/kg, i.p.) and antagonised the reduction of motion sickness induced by morphine. In animals that received saline or naloxone (1.0 mg/kg), a motion stimulus inducing emesis decreased the responsiveness of animals to a second and subsequent motion stimulus challenge when applied every 2 days for 11 trials. However, the animals receiving naloxone 10.0 mg/kg prior to the second and subsequent challenges showed no significant reduction in the intensity of emesis compared to the first trial. The data are revealing of an emetic potential of morphine when administered in the presence of a naloxone pretreatment. The administration of naloxone is also revealing of an additional inhibitory opioid system whose activation by endogenous opioid(s) may play a role in the adaptation to motion sickness on repeated challenge in S. murinus.
机译：本研究的目的是研究阿片类受体参与了对日光斑动晕病适应性反应。在无水平运动或水平运动前30分钟，分别用盐水，吗啡（0.1和1.0 mg / kg），纳洛酮（1.0、10.0和5.0 mg / kg）或纳洛酮加吗啡的组合腹膜内治疗不同组的动物1 Hz和40 mm振幅的刺激。为了进行适应性研究，不同组在第一次试验中接受了盐水，在随后的试验中（每2天），他们接受了盐水，纳洛酮（1.0和10.0 mg / kg，腹膜内）或吗啡（0.1 mg / kg，腹膜内）运动刺激前30分钟。用吗啡进行预处理会导致单次运动刺激引起的呕吐剂量相关的减少。单独使用纳洛酮进行预处理本身并不能诱发呕吐，也不能改变由单一刺激刺激引起的呕吐。但是，用纳洛酮（5.0 mg / kg，i.p.）预处理显示出对吗啡的催吐反应（P <.001）（1.0 mg / kg，i.p.），并且拮抗吗啡引起的晕车病的减轻。在接受生理盐水或纳洛酮（1.0 mg / kg）治疗的动物中，每11天每2天施用一次运动刺激诱导的呕吐，会降低动物对第二次和随后的运动刺激刺激的反应。但是，与第一次试验相比，在第二次和随后的攻击之前接受纳洛酮10.0 mg / kg的动物显示呕吐强度没有明显降低。数据揭示了在纳洛酮预处理条件下给药时吗啡具有催吐作用。纳洛酮的给药还揭示了另外的抑制性阿片样物质系统，其通过内源性阿片样物质的激活可能在反复感染沙门氏菌时对晕动病的适应中起作用。

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