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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Differential sensitivity to the anxiolytic effects of ethanol and flunitrazepam in PKCgamma null mutant mice.
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Differential sensitivity to the anxiolytic effects of ethanol and flunitrazepam in PKCgamma null mutant mice.

机译：对PKCgamma null突变小鼠中乙醇和氟尼西epa的抗焦虑作用的差异敏感性。

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Tests of ethanol effects in PKCgamma null mutant mice have indicated that PKCgamma plays a role in initial sensitivity to ethanol-induced sedation, hypothermia, and GABA(A) receptor function and impacts neurochemical pathways mediating anxiety. The present study was undertaken to evaluate whether the decreased sensitivity to ethanol previously observed in these mice generalized to the anxiolytic effects of ethanol. PKCgamma null mutant mice and wild-type controls were tested in the elevated-plus maze, the black/white box, and the mirrored chamber after ethanol (0, 1.0, 1.25, 1.5 g/kg) or flunitrazepam (FNZ) (0, 0.015, 0.03, 0.06 mg/kg). Results indicated that although both genotypes exhibited anxiolytic responses to ethanol in the elevated plus-maze, null mutant mice were less sensitive than wild-type control mice; however, in the black/white box, PKCgamma null mutants were more sensitive than controls to the anxiolytic effects of FNZ. Neither ethanol nor FNZ produced anxiolytic responses in the mirrored chamber for either genotype. These results suggest that PKCgamma differentially mediates anxiolytic responses to ethanol and FNZ and that this relationship interacts with each drug's efficacy in reducing anxiety-related behaviors specific to each of the three mazes.
机译：PKCgamma null突变小鼠中乙醇作用的测试表明，PKCgamma在对乙醇诱导的镇静，低温和GABA（A）受体功能的初始敏感性中起作用，并影响介导焦虑的神经化学途径。进行本研究以评估先前在这些小鼠中观察到的对乙醇的敏感性降低是否普遍归因于乙醇的抗焦虑作用。在乙醇（0，1.0，1.25，1.5 g / kg）或氟硝西m（FNZ）（0， 0.015、0.03、0.06 mg / kg）。结果表明，尽管两种基因型在升高的迷宫中均表现出对乙醇的抗焦虑反应，但无效突变小鼠的敏感性低于野生型对照小鼠。然而，在黑色/白色框中，PKCgamma null突变体对FNZ的抗焦虑作用比对对照更为敏感。乙醇和FNZ均未在镜像室中产生任何基因型的抗焦虑反应。这些结果表明，PKCgamma差异介导了对乙醇和FNZ的抗焦虑反应，并且这种关系与每种药物在减少特定于三种迷宫的焦虑相关行为中的功效相互作用。

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