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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The inability of CCK to block (or CCK antagonists to substitute for) the stimulus effects of chlordiazepoxide.
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The inability of CCK to block (or CCK antagonists to substitute for) the stimulus effects of chlordiazepoxide.

机译：CCK无法阻止（或CCK拮抗剂替代）氯二氮卓的刺激作用。

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摘要

To further examine the relationship between cholecystokinin (CCK) and GABA, the present study assessed the ability of the CCK-A antagonist devazepide and the CCK-B antagonist L-365,260 to substitute for the stimulus effects of chlordiazepoxide (CDP), as well as the ability of CCK-8s to block these effects, in female Long-Evans rats within the conditioned taste aversion baseline of drug discrimination learning. Both devazepide and L-365,260 failed to substitute for the discriminative stimulus properties of CDP, and CCK-8s failed to block its stimulus effects. The benzodiazepine diazepam did substitute for, and the benzodiazepine antagonist flumazenil did block, the stimulus effects of CDP. This suggests that the lack of substitution for, or antagonism of, CDP by the CCK antagonists and CCK-8s, respectively, was not due to the inability of the present design to assess such effects. Possible bases for the current findings, e.g., necessity of an anxiogenic baseline, drug and receptor specificity, as well as the dose-response nature of the interaction, were discussed. Given that a relationship between CCK and GABA has been reported in other designs, the present results suggest that such a relationship may be preparation specific.
机译：为了进一步检查胆囊收缩素（CCK）和GABA之间的关系，本研究评估了CCK-A拮抗剂devazepide和CCK-B拮抗剂L-365,260替代氯二氮卓（CDP）的刺激作用的能力，以及在药物辨别学习的条件化味觉回避基线内的雌性Long-Evans大鼠中，CCK-8阻断这些作用的能力。 devazepide和L-365,260均不能替代CDP的歧视性刺激特性，CCK-8s不能阻止其刺激效果。苯二氮卓地西did确实替代了CDP的刺激作用，而苯二氮卓拮抗剂氟马西尼确实阻止了CDP的刺激作用。这表明CCK拮抗剂和CCK-8分别缺乏对CDP的替代或拮抗作用，并不是由于本设计无法评估此类作用。讨论了当前发现的可能基础，例如，焦虑发生基线的必要性，药物和受体的特异性以及相互作用的剂量反应性质。假定在其他设计中已经报道了CCK和GABA之间的关系，则本结果表明这种关系可能是特定于制剂的。

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