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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Dose-discrimination performance of mice for self-administration of morphine into the lateral hypothalamus.
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Dose-discrimination performance of mice for self-administration of morphine into the lateral hypothalamus.

机译：小鼠向下丘脑外侧自我施用吗啡的剂量区分性能。

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摘要

Two experiments were performed in BALB/c mice implanted bilaterally with guide cannulae. In the first experiment, the tips of the guide cannulae were positioned 1.5 mm above the lateral hypothalamus (LH). On each experimental day, injection cannulae were inserted into each side of the LH. The experiment, carried out in a Y-maze, was composed of two phases. During the initial acquisition period, which lasted 4 days, animals were allowed to self-inject, successively, on alternate days, one dose of morphine into one side of the LH and a different dose in the other side. From the fifth day, the subjects were given the possibility of choosing between these two doses by entering into a given arm of the Y-maze. When the two doses available were 5 ng and 50 ng or 15 ng and 50 ng, the subjects rapidly discriminated them and preferentially triggered the injection of the higher dose (50 ng). When the two doses available were 30 ng and 50 ng, the mice triggered indifferently the two doses during the first three sessions. A discrimination between these two doses began to become apparent from the fourth session, with the subjects preferring to trigger the dose of 50 ng. In a second experiment, the tips of the guide cannulae were positioned either 1.5 mm or 2.6 mm above the LH, the bilateral injection cannulae consequently being inserted either into the LH or into the overlying ventral thalamus (TH). Experimental conditions were the same as that of Experiment 1.(ABSTRACT TRUNCATED AT 250 WORDS)
机译：在两侧植入引导套管的BALB / c小鼠中进行了两个实验。在第一个实验中，引导套管的尖端位于下丘脑外侧（LH）上方1.5毫米处。在每个实验日，将注射套管插入LH的每一侧。在Y型迷宫中进行的实验由两个阶段组成。在为期4天的初始采集期中，允许动物在隔日连续自我注射LH一侧的一剂吗啡和另一侧的另一剂。从第五天起，通过进入给定的Y型迷宫手臂，受试者可以在这两个剂量之间进行选择。当两种可用剂量分别为5 ng和50 ng或15 ng和50 ng时，受试者迅速对其进行区分，并优先触发了更高剂量（50 ng）的注射。当可用的两个剂量分别为30 ng和50 ng时，小鼠在前三个疗程中无差别地触发了这两个剂量。从第四节开始，这两种剂量之间的区别开始变得明显，受试者更喜欢触发50 ng剂量。在第二个实验中，将引导套管的尖端定位在LH上方1.5 mm或2.6 mm处，因此将双侧注射套管插入LH或上方的腹侧丘脑（TH）中。实验条件与实验1相同（摘要以250字截断）

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