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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Tail pinch increases acetylcholine release in rat striatum even after toluene exposure.
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Tail pinch increases acetylcholine release in rat striatum even after toluene exposure.

机译：即使在甲苯接触后，尾巴捏合也会增加大鼠纹状体中乙酰胆碱的释放。

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摘要

The effect of tail pinch on acetylcholine release in the striatum of freely moving rats was studied by microdialysis immediately after inhalation exposure to toluene (2000 ppm, 2 h) or exposure to air only. It has recently been found that toluene increases extracellular dopamine levels while decreasing acetylcholine release, and that dopamine uptake inhibition increases both extracellular dopamine levels and acetylcholine release, suggesting that toluene decreases acetylcholine release by a dopamine-independent mechanism. The present experiment was an attempt to study if a behaviourally induced increase of extracellular dopamine differs from that induced by toluene in affecting striatal acetylcholine release. Acetylcholine released increased during tailpinch in the unexposed as well as the toluene exposed group. No difference between the two groups in the acetylcholine release response to tailpinch was demonstrated. The result supports the conclusion that acute toluene exposure decreases acetylcholine release via a dopamine independent mechanism, and suggests that toluene exposure does not affect the striatal acetylcholine response to an acute stressful stimulus.
机译：吸入甲苯（2000 ppm，2 h）或仅暴露于空气后立即通过微透析研究了尾巴收缩对自由移动大鼠纹状体中乙酰胆碱释放的影响。最近发现，甲苯增加了细胞外多巴胺的水平，同时降低了乙酰胆碱的释放，并且多巴胺摄取抑制作用增加了细胞外多巴胺的水平和乙酰胆碱的释放，这表明甲苯通过多巴胺非依赖性机制降低了乙酰胆碱的释放。本实验试图研究行为诱导的细胞外多巴胺的增加是否与甲苯诱导的影响纹状体乙酰胆碱释放的增加不同。未暴露的组和甲苯暴露组在尾巴捏期间释放的乙酰胆碱增加。两组之间对尾巴的乙酰胆碱释放反应没有差异。该结果支持以下结论：急性甲苯暴露通过多巴胺非依赖性机制降低乙酰胆碱的释放，并表明甲苯暴露不影响纹状体乙酰胆碱对急性应激刺激的反应。

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